Human Reproduction, Vol. 17, No. 10, 2654-2656,
October 2002
© 2002 European Society of Human Reproduction and Embryology
Semen production in adolescent cancer patients
1 Royal Free and University College Medical School, Department of Obstetrics & Gynaecology, Fertility and Reproductive Medicine Laboratories, University College Hospitals Trust, 88–96 Chenies Mews, London WC1E 6HX, 2 Department of Medicine, University Street, London WC1E 6AU, 3 Institute of Urology St. Peters & Middlesex Hospital, London W1N 8AA and 4 Middlesex Hospital, Mortimer Street, London W1N 8AA, UK
BACKGROUND: The influence of an accompanying person (parent, guardian or nurse) on the ability of an adolescent (post-pubescent, <20 years of age) to produce a semen sample for cryopreservation, is undetermined, as is the potential for use of urine samples to retrieve sperm in those adolescents that are unable to produce a semen sample. METHODS: The records from 1991–2000 inclusive were reviewed to derive those adolescent patients who were unable to produce semen for cryopreservation prior to undergoing treatment for a malignant condition. RESULTS: During the study period 238 adolescents attended our unit of whom 205 (86.1%) banked semen (‘producers’). The remaining 33 adolescents (13.9%) were initially unable to produce a sample (‘non-producers’), four of these provided a urine specimen for analysis (12.1%) and of these one had sufficient sperm for cryopreservation. Of the ‘accompanied’ patients 29.7% (19/64) were non-producers while in the ‘unaccompanied’ patients only 8.0% (14/174) were non-producers (
2 = 16.58, P < 0.001). The relative risk (RR) of not producing a semen sample for the accompanied group of patients was greater than that for the unaccompanied group (RR = 3.689, 95% confidence interval: 2.0–6.9). One patient returning alone successfully provided a semen sample for storage. CONCLUSION: Units should consider the effect of the presence of an accompanying person when an adolescent is unable to produce a semen sample and should consider requesting urine to retrieve sperm.
Key words: adolescent/cancer/cryopreservation/sperm/spermaturia
5 To whom correspondence should be addressed. E-mail: g.bahadur{at}ucl.ac.uk
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