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Human Reproduction, Vol. 17, No. 12, 3016-3026, December 2002
© 2002 European Society of Human Reproduction and Embryology

Debate continued

Should patients with polycystic ovary syndrome be treated with metformin?

Benefits of insulin sensitizing drugs in polycystic ovary syndrome—beyond ovulation induction

Laurel A. Stadtmauer1, Benjamin C. Wong and Sergio Oehninger

The Howard and Georgeanna Jones Institute for Reproductive Medicine, 601 Colley Avenue, Norfolk, VA 23507, USA

The debate on metformin use in polycystic ovary syndrome (PCOS) has mainly focused on its treatment for infertility in ovulation induction and menstrual cyclicity. Here we will summarize the data supporting the effect of metformin on improving hyperandrogenaemia and hyperinsulinaemia in PCOS patients. We propose that metformin benefits PCOS patients undergoing gonadotrophin therapy and IVF as well as ovulation induction. We also advocate the use of insulin sensitizing drugs to reduce miscarriage rates, and risks associated with coronary artery disease, gestational diabetes and obesity.

Key words: hyperandrogenism/insulin resistance/metformin/polycystic ovary syndrome

1 To whom correspondence should be addressed. E-mail: stadtmla{at}evms.edu


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