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Human Reproduction, Vol. 17, No. 3, 560-563, March 2002
© 2002 European Society of Human Reproduction and Embryology

Studies on the human leukocyte antigen-DR in patients with endometriosis: genotyping of HLA-DRB1 alleles

Keisuke Ishii,1, Koichi Takakuwa, Takuya Mitsui and Kenichi Tanaka

Department of Obstetrics and Gynecology, Niigata University School of Medicine, 1-757, Asahimachi-dori, Niigata, 951-8510, Japan

BACKGROUND: An increasing number of reports suggest that endometriosis is associated with abnormal immune function involving changes in both cell-mediated and humoral immunity, although the aetiology of the disease remains undefined. The human leukocyte antigen system (HLA) is known to play a role in the aetiology of a number of diseases. This study examines the possible association between the HLA-DR and endometriosis. METHODS: Eighty-three patients diagnosed with endometriosis by laparoscopic examination were typed for HLA-DR antigens using a PCR–restriction fragment length polymorphism analysis. The frequency of HLA-DR genotypes in this patient population was compared with that in a population of general controls. RESULTS: The incidence of HLA-DRB1*1403 in the patient group was 6.0% (10/166 alleles) compared with 1.4% in the control group (6/444 alleles), and the incidence of the HLA-DRB1*1403 allele was significantly greater in patients with endometriosis compared with the control population [odds ratio 4.68, 95% confidence interval 1.67–13.09, P = 0.0013 ({chi}2 analysis), (corrected P values: Pc = 0.0494)]. No significant difference was found between the two groups with regards to the frequency of the other HLA-DR alleles. CONCLUSIONS: The results from this study may be helpful to implicate a role of HLA-DR antigens in the development of endometriosis, although further investigation is required.

Key words: endometriosis/HLA-DRB1 genotypes/PCR/RFLP

1 To whom correspondence should be addressed. E-mail: keisui28{at}med.niigata-u.ac.jp

Submitted on January 29, 2001; resubmitted on July 13, 2001


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