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Human Reproduction, Vol. 17, No. 4, 926-928, April 2002
© 2002 European Society of Human Reproduction and Embryology

Comparison of day 3 FSH serum values as determined by six different immunoassays

Joëlle Taieb1,3, François Olivennes2, Anne Sophie Birr1, Clarisse Benattar1, Claudia Righini2, René Frydman2 and Albert Lindenbaum1

1 Department of Biochemistry and Hormonology and 2 Department of Obstetrics and Gynecology and Reproductive Endocrinology, Hôpital Antoine Béclère, Clamart, France

BACKGROUND: The accurate assessment of FSH concentration is important for evaluating ovarian function prior to IVF. However, a number of different assay techniques are currently in use, leading to inconsistencies in the hormone data being reported. To address this problem, we measured FSH concentration using a number of commercially available systems. METHODS: Day 3 serum FSH levels were measured in 215 healthy fertile women using six different immunoassays: Coatria 125I (Bio-Mérieux), ACS-180 (Bayer Diagnostics), Advia-Centaur (Bayer Diagnostics), Vitros ECi (Ortho-Clinical Diagnostics), Architect i2000 (Abbott) and Elecsys 2010 (Roche Diagnostics). RESULTS: According to the immunoassay, means ± SD of FSH concentrations were: 6.5 ± 2.2 mIU/ml for Coatria 125I, 6.8 ± 2.7 mIU/ml for Advia-Centaur, 6.7 ± 3.0 mIU/ml for Vitros ECi, 7.6 ± 3.0 mIU/ml for ACS-180, 8.2 ± 3.3 mIU/ml for Architect i2000 and 8.8 ± 3.0 mIU/ml for Elecsys 2010. CONCLUSION: Day 3 FSH values determined by six different immunoassays were significantly different (P < 0.01, paired t-test). Physicians must take care when interpreting results from different clinical laboratories.

Key words: FSH/immunoassay/menstrual cycle

3 To whom correspondence should be addressed at: Department of Biochemistry and Hormonology, Hôpital Antoine Béclère, 157 rue de la porte de Trivaux, 92141 Clamart, France. E-mail: joelle.taieb{at}abc.ap-hop-paris.fr


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