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Human Reproduction, Vol. 17, No. 5, 1222-1225, May 2002
© 2002 European Society of Human Reproduction and Embryology

A randomized, double blind, placebo-controlled study to investigate the use of conscious sedation in conjunction with paracervical block for reducing pain in termination of first trimester pregnancy by suction evacuation

C.Y.G. Wong,1, E.H.Y. Ng, S.W. Ngai and P.C. Ho

Department of Obstetrics and Gynaecology, Queen Mary Hospital, University of Hong Kong, Hong Kong, China

BACKGROUND: This study evaluated the role of conscious sedation in pain relief during termination of first trimester pregnancy by suction evacuation (SE) under local anaesthesia. METHODS: A hundred women undergoing SE before 12 weeks gestation were randomized by computer using the sealed envelope method to receive placebo (saline) or conscious sedation (2 mg midazolam and 25 µg fentanyl) i.v. 5 min before cervical dilatation. Paracervical block was given to all patients, 2 min later. Pain scores during and after SE, post-operative side-effects and satisfaction level were compared. RESULTS: No statistically significant differences in pain scores were found between the two groups. Post-operative side-effects such as dizziness (P = 0.015) and drowsiness (P < 0.001) were significantly more severe in the conscious sedation group. However, patients in the conscious sedation group reported better satisfaction levels than the control group (P = 0.003). CONCLUSION: The use of conscious sedation significantly improved patient satisfaction during termination of first trimester pregnancy by SE under local anaesthesia, despite a lack of improvement in pain relief and the presence of increased severe dizziness/drowsiness in the post-operative period.

Key words: conscious sedation/pain relief/paracervical block/suction evacuation/termination of pregnancy

1 Department of Obstetrics & Gynaecology, 6/F Professorial Block, Queen Mary Hospital, Pokfulam Road, Hong Kong, China. E-mail: wongcyg{at}yahoo.com


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A. S. Y. Kan, N. Caves, S. Y. W. Wong, E. H. Y. Ng, and P. C. Ho
A double-blind, randomized controlled trial on the use of a 50:50 mixture of nitrous oxide/oxygen in pain relief during suction evacuation for the first trimester pregnancy termination
Hum. Reprod., October 1, 2006; 21(10): 2606 - 2611.
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