Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (35)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Balaban, B.
Right arrow Articles by Isiklar, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Balaban, B.
Right arrow Articles by Isiklar, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 17, No. 5, 1239-1243, May 2002
© 2002 European Society of Human Reproduction and Embryology

A comparison of four different techniques of assisted hatching

Basak Balaban, Bulent Urman,1, Cengiz Alatas, Ramazan Mercan, Alper Mumcu and Aycan Isiklar

Assisted Reproduction Unit, American Hospital of Istanbul, Istanbul, Turkey

BACKGROUND: Assisted hatching (AH) has been proposed as a means to increase the implantation rate in patients with poor prognosis for pregnancy. The procedure appears to be effective when used selectively. Several different methods for AH have been introduced over the years but comparative studies are lacking. The aim of the current study was to compare retrospectively the efficacy of AH performed with four different methods in patients undergoing IVF or ICSI. METHODS: AH was performed prior to day 3 embryo transfer in 794 IVF/ICSI cycles. Indications for AH were females aged >35 years and/or elevated follicular phase FSH levels, previous failed IVF/ICSI cycles, poor embryo quality, and thick zona pellucida (>15 µm). Assignment to one of the four methods of AH was according to the availability of the particular method during the study period. The study was not randomized. RESULTS: Partial zona dissection was used in 239, acid Tyrode in 191, diode laser in 219 and pronase thinning of the zona pellucida in 145. Mean female age, mean number of previous failed IVF/ICSI cycles, number of oocytes retrieved, fertilization and cleavage rates, good quality embryos and zona thickness on day 3 did not differ between groups. Mean number of embryos transferred, implantation rate, clinical pregnancy rate, and abortion rates were likewise similar. CONCLUSIONS: Selective AH using four different methods yields similar implantation and pregnancy rates.

Key words: assisted hatching/implantation/IVF

1 To whom correspondence should be addressed at: VKV American Hospital, Guzelbahce sok. No:20, Nisantasi 80200, Istanbul, Turkey. E-mail: burman{at}superonline.com


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
C. Sifer, A. Sellami, C. Poncelet, P. Kulski, B. Martin-Pont, J. Bottero, R. Porcher, I. Cedrin-Durnerin, J.N. Hugues, and J.P. Wolf
A prospective randomized study to assess the benefit of partial zona pellucida digestion before frozen-thawed embryo transfers
Hum. Reprod., September 1, 2006; 21(9): 2384 - 2389.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
B. Balaban, B. Urman, K. Yakin, and A. Isiklar
Laser-assisted hatching increases pregnancy and implantation rates in cryopreserved embryos that were allowed to cleave in vitro after thawing: a prospective randomized study
Hum. Reprod., August 1, 2006; 21(8): 2136 - 2140.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
T. Ebner, M. Moser, and G. Tews
Possible applications of a non-contact 1.48 {micro}m wavelength diode laser in assisted reproduction technologies
Hum. Reprod. Update, July 1, 2005; 11(4): 425 - 435.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
Q.F. Lyu, L.Q. Wu, Y.P. Li, Q. Pan, D.E. Liu, K. Xia, D.S. Liang, F. Cai, Z.G. Long, H.P. Dai, et al.
An improved mechanical technique for assisted hatching
Hum. Reprod., June 1, 2005; 20(6): 1619 - 1623.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. H. Y. Ng, F. Naveed, E. Y. L. Lau, W. S. B. Yeung, C. C. W. Chan, O. S. Tang, and P. C. Ho
A randomized double-blind controlled study of the efficacy of laser-assisted hatching on implantation and pregnancy rates of frozen-thawed embryo transfer at the cleavage stage
Hum. Reprod., April 1, 2005; 20(4): 979 - 985.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
M.-P. Primi, A. Senn, M. Montag, H. Van der Ven, J. Mandelbaum, A. Veiga, P. Barri, and M. Germond
A European multicentre prospective randomized study to assess the use of assisted hatching with a diode laser and the benefit of an immunosuppressive/antibiotic treatment in different patient populations
Hum. Reprod., October 1, 2004; 19(10): 2325 - 2333.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
H. Joris, A. De Vos, R. Janssens, P. Devroey, I. Liebaers, and A. Van Steirteghem
Comparison of the results of human embryo biopsy and outcome of PGD after zona drilling using acid Tyrode medium or a laser
Hum. Reprod., September 1, 2003; 18(9): 1896 - 1902.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.