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Human Reproduction, Vol. 17, No. 5, 1244-1248, May 2002
© 2002 European Society of Human Reproduction and Embryology

The effect on IVF outcome of small intramural fibroids not compressing the uterine cavity as determined by a prospective matched control study

J.H. Check,1, J.K. Choe, G. Lee and C. Dietterich

The University of Medicine and Dentistry of New Jersey, Robert Wood Johnson Medical School at Camden, Cooper Hospital/University Medical Center, Department of Obstetrics and Gynecology, Division of Reproductive Endocrinology & Infertility, Camden, New Jersey, USA

BACKGROUND: Several studies have reported that the presence of intramural fibroids affects conception following IVF. We attempted to corroborate or refute the conclusions relating to IVF and leiomyomas of the aforementioned studies. METHODS: Women with small intramural leiomyomata (<=5 cm) discovered on initial pelvic sonographic studies performed in preparation for IVF were prospectively matched by age, with the next patient of the same age undergoing IVF who did not demonstrate fibroids (controls). RESULTS: Though no significant differences were found in outcome when comparing these two groups, there was a distinct trend for lower live delivery rates and higher miscarriage rates. CONCLUSIONS: These data support the conclusions of the only other prospective matched control study evaluating similar factors, i.e. that small intramural fibroids can negatively affect IVF outcome. Nevertheless, we think that a multicentre study should be conducted first before evaluating whether myomectomy improves outcome or not.

Key words: IVF/leiomyoma/matched controls/pregnancy rates/pre-term delivery

1 To whom correspondence should be addressed at: 7447 Old York Road, Melrose Park, PA 19027, USA. E-mail: laurie{at}ccivf.com


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