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Human Reproduction, Vol. 17, No. 6, 1591-1596, June 2002
© 2002 European Society of Human Reproduction and Embryology

Follicular fluid and serum concentrations of myo-inositol in patients undergoing IVF: relationship with oocyte quality

Tony T.Y. Chiu1,3, Michael S. Rogers1, Eric L.K. Law2, Christine M. Briton-Jones1, L.P. Cheung1 and Christopher J. Haines1

1 Department of Obstetrics and Gynaecology and 2 Department of Chemical Pathology, Faculty of Medicine, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China

BACKGROUND: The follicular microenvironment is an important determinant of oocyte development. The aim of this study was to examine whether the myo-inositol (MI) content in human follicular fluid (FF) was associated with better oocyte quality. METHODS: A total of 53 patients treated with IVF was recruited to a prospective observational study. FF and serum samples collected were divided into two groups: group A consisted of FF associated with matured and fertilized oocytes, whilst group B was from follicles with immature and unfertilized oocytes. RESULTS: Patient's age, total ampoules of HMG used, days of stimulation, basal levels of FSH, estradiol (E2) levels on the day of HCG, and serum MI content were not significantly different between the two groups. FF volume and its MI content were significantly higher in group A compared with group B (P < 0.05). The levels of MI in FF were positively correlated with the amount of E2 in their corresponding FF samples and also correlated with embryo quality. CONCLUSIONS: We propose that higher concentrations of MI and E2 in human FF appear to play a role in follicular maturity and provide a marker of good quality oocytes.

Key words: estradiol/follicular fluid/IVF/myo-inositol/oocyte

3 To whom correspondence should be addressed. E-mail: tonychiu{at}cuhk.edu.hk


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