Human Reproduction, Vol. 17, No. 8, 2009-2015,
August 2002
© 2002 European Society of Human Reproduction and Embryology
Modulation of folliculogenesis and steroidogenesis in women by graded menotrophin administration
Reproductive Endocrinology Centre, University of Bologna, Bologna, Italy
BACKGROUND: To test the effects of progressively decreasing dosages of exogenous LH we combined various amounts of HMG, containing FSH, LH and HCG, and highly purified (HP) FSH to treat 120 GnRH agonist-suppressed infertile female patients as candidates for controlled ovarian stimulation (COS). METHODS: Subjects were randomly assigned to four treatment groups that received the following daily i.m. gonadotrophin regimens: A, FSH 150 IU only; B, FSH 150 IU and LH activity 37.5 IU; C, FSH 150 IU and LH activity 75 IU; D, FSH 150 IU and LH activity 150 IU. FSH dose adjustments were allowed only after the 14th treatment day. Monitoring included transvaginal ultrasound at 2-day intervals and daily determinations of LH, FSH, estradiol (E2), progesterone, testosterone and HCG. RESULTS: Duration of COS was significantly shortened in patients receiving at least 75 IU daily of LH activity. Small (<10 mm diameter) pre-ovulatory ovarian follicle occurrence was inversely correlated with LH activity dose administered (r = -0.648, P < 0.0001) and serum HCG levels (r = -0.272, P < 0.01) but not to serum LH levels. Serum testosterone levels were positively correlated to the LH activity dose administered (r = 0.313, P < 0.001), while serum progesterone levels were positively correlated to the FSH dose administered (r = 0.447, P < 0.00001) but not to the LH activity dose administered. CONCLUSIONS: Firstly, HCG content considerably contributes to HMG activity; secondly, menotrophin LH activity content can reduce in a dose-dependent manner the occurrence of small pre-ovulatory follicles; and finally, contrary to common belief, enhanced FSH stimulation rather than LH activity appears to cause premature follicle luteinization during COS.
Key words: follicle-stimulating hormone/human chorionic gonadotrophin/luteinizing hormone/ovarian follicle/ovulation induction
1 To whom correspondence should be addressed at: Reproductive Endocrinology Centre, Department of Obstetrics and Gynaecology, University of Bologna, Via Massarenti 13, 40138 Bologna, Italy. E-mail: filicori{at}med.unibo.It
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Bosch, C. Vidal, E. Labarta, C. Simon, J. Remohi, and A. Pellicer Highly purified hMG versus recombinant FSH in ovarian hyperstimulation with GnRH antagonists--a randomized study Hum. Reprod., October 1, 2008; 23(10): 2346 - 2351. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. Bosch Comment on: Is progesterone elevation on the day of human chorionic gonadotrophin administration associated with the probability of pregnancy in in vitro fertilization? A systematic review and meta-analysis. By Venetis et al (2007) Hum. Reprod. Update, March 1, 2008; 14(2): 194 - 195. [Full Text] [PDF]
|
|
|
|
 |
|
 M. B. Stanek, S. M. Borman, T. A. Molskness, J. M. Larson, R. L. Stouffer, and P. E. Patton Insulin and Insulin-Like Growth Factor Stimulation of Vascular Endothelial Growth Factor Production by Luteinized Granulosa Cells: Comparison between Polycystic Ovarian Syndrome (PCOS) and Non-PCOS Women J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2726 - 2733. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Andersen, P. Devroey, and J.-C. Arce Reply: Comparing highly purified hMG and rFSH in patients undergoing IVF Hum. Reprod., June 1, 2007; 22(6): 1798 - 1800. [Full Text] [PDF]
|
|
|
|
|
|
J. Smitz, A.N. Andersen, P. Devroey, J.-C. Arce, and for the MERIT Group Endocrine profile in serum and follicular fluid differs after ovarian stimulation with HP-hMG or recombinant FSH in IVF patients Hum. Reprod., March 1, 2007; 22(3): 676 - 687. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. N. Andersen, P. Devroey, J.-C. Arce, and for the MERIT Group Clinical outcome following stimulation with highly purified hMG or recombinant FSH in patients undergoing IVF: a randomized assessor-blind controlled trial Hum. Reprod., December 1, 2006; 21(12): 3217 - 3227. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.A.B. Melo, M. Meseguer, N. Garrido, E. Bosch, A. Pellicer, and J. Remohi The significance of premature luteinization in an oocyte-donation programme Hum. Reprod., June 1, 2006; 21(6): 1503 - 1507. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. Loumaye, P. Engrand, Z. Shoham, S.G. Hillier, and D.T. Baird Clinical evidence for an LH ceiling? Hum. Reprod., December 1, 2003; 18(12): 2719 - 2720. [Full Text] [PDF]
|
|
|
|
|
|
M. Filicori, G. E. Cognigni, and W. Ciampaglia What clinical evidence for an LH ceiling? Hum. Reprod., July 1, 2003; 18(7): 1556 - 1557. [Full Text] [PDF]
|
|
|
|
|
|
M. Filicori, G. E. Cognigni, and W. Ciampaglia Effects of LH on oocyte yield and developmental competence Hum. Reprod., June 1, 2003; 18(6): 1357 - 1358. [Full Text] [PDF]
|
|