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Human Reproduction, Vol. 17, No. 8, 2073-2078, August 2002
© 2002 European Society of Human Reproduction and Embryology

HLA DQ alleles and interleukin-10 polymorphism associated with Chlamydia trachomatis-related tubal factor infertility: a case–control study

A.H. Kinnunen1, H-M. Surcel1,7, M. Lehtinen2, J. Karhukorpi3, A. Tiitinen4, M. Halttunen4, A. Bloigu1, R.P. Morrison5, R. Karttunen6 and J. Paavonen4

1 National Public Health Institute, 90101 Oulu, 2 National Public Health Institute, Helsinki, 3 Clinical Microbiology Laboratory, University Hospital of Oulu, 4 Department of Obstetrics and Gynecology, University of Helsinki, Helsinki, Finland, 5 Department of Microbiology, Montana State University, Bozeman, MT, USA and 6 Department of Medical Microbiology, University of Oulu, Oulu, Finland

BACKGROUND: The relationship between Chlamydia trachomatis tubal factor infertility (TFI) and the host’s immunoregulatory genes was studied. METHODS: Cell-mediated immune responses to C. trachomatis and chlamydial heat shock protein (CHSP60) were determined by lymphocyte proliferation assay. HLA-DQ alleles and interleukin-10 (IL-10) promoter polymorphism (–1082 A/G) were analysed in 52 TFI cases and in 61 controls by PCR. RESULTS: HLA-DQB1 or DQA1 alleles did not significantly differ between the TFI group and the control group. However, DQA1*0102 and DQB1*0602 alleles together with IL-10 –1082AA genotype were found significantly more frequently in the TFI patients than in the controls (0.18 and 0.02 respectively; P = 0.005). Five (22%) of the 23 patients who had a positive lymphocyte proliferative response to CHSP60 were positive also for IL-10 –1082AA and for the HLA-DQA1*0102 and HLA-DQB1*0602 alleles. CONCLUSIONS: Our results reveal an association of a cellular immune response to CHSP60, HLA class II alleles and IL-10 promoter genotypes in patients with chlamydial TFI.

Key words: Chlamydia trachomatis/CHSP60/HLA alleles/infertility/interleukin-10

7 To whom correspondence should be addressed. E-mail: Helja-Marja.Surcel{at}ktl.fi


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