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Human Reproduction, Vol. 17, No. 8, 2112-2118, August 2002
© 2002 European Society of Human Reproduction and Embryology

Semen alterations in HIV-1 infected men

E. Dulioust1,8, A.Le Du1, D. Costagliola2, J. Guibert3, J.-M. Kunstmann1, I. Heard4, J.-C. Juillard1, D. Salmon5, M. Leruez-Ville6, L. Mandelbrot7, C. Rouzioux6, D. Sicard5, J.-R. Zorn3, P. Jouannet1 and M. De Almeida1

1 Laboratoire de Biologie de la Reproduction, GREFH, Hôpital Cochin-APHP, Université Paris 5, 123 Bd de Port Royal, 75014 Paris, 2 INSERM EMI 0214, 56 Bd Vincent Auriol, 75013, Paris, 3 Service de Gynécologie-Obstétrique 3, Hôpital Cochin-APHP, 123 Bd de Port Royal, 75014 Paris, 4 Service de Gynécologie, Hôpital Européen Georges Pompidou-APHP, 20 rue Leblanc, 75015 Paris, 5 Service de Médecine Interne 2, Hôpital Cochin-APHP, 27 Rue du Faubourg Saint-Jacques, 75014 Paris, 6 Laboratoire de Virologie, Hôpital Necker-Enfants Malades-APHP, 149 rue de Sèvres, 75015 Paris and 7 Service de Gynécologie-Obstétrique 1, Hôpital Cochin-APHP, 123 Bd de Port Royal, 75014 Paris, France

BACKGROUND: Couples in whom the man is infected by human immunodeficiency virus (HIV) increasingly request assisted reproductive technology (ART) to allow safe procreation. Semen quality is critical in such situations. METHODS: Semen characteristics were evaluated in 189 HIV-infected men requesting ART. At the time of semen analysis all men were healthy and 177 were receiving anti-retroviral therapy. Comparisons were made with HIV-seronegative men, partners of women requiring IVF because of tubal infertility, after matching for age and sexual abstinence delay. RESULTS: The most significant semen alterations found in the HIV-infected men were reduced percentages of rapidly progressive sperm [median (range), 10% (0–30%) compared with 15% (5–30%) in the controls, P < 0.001], and increased concentrations of non-spermatic cells [3x106/ml (0.2–16x106/ml) compared with 1.1x106/ml (0.1–14x106/ml) in the controls, P < 0.001]. HIV-infected men also showed lower ejaculate volumes [2.8 ml (0.6–9.3 ml) compared with 3.6 ml (1.1–11 ml), P < 0.05] and total sperm counts [262.5x106 (0–1003x106) compared with 310.5x106 (48.3–1679x106), P < 0.05]. CONCLUSIONS: Semen evaluation in a large population of HIV-infected men requesting ART evidenced several alterations. Some of these anomalies might be related to anti-retroviral treatments.

Key words: HIV-1/semen analysis/sperm motility

8 To whom correspondence should be addressed. E-mail: emmanuel.dulioust{at}cch.ap-hop-paris.fr


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