Human Reproduction, Vol. 17, No. 9, 2331-2337,
September 2002
© 2002 European Society of Human Reproduction and Embryology
Serum inhibin B levels measured early during FSH administration for IVF may be of value in predicting the number of oocytes to be retrieved in normal and low responders
1 IVF Unit, Department of Obstetrics and Gynecology, 2 Institute of Hormone Research Shaare-Zedek Medical Center, Ben-Gurion University, P.O.Box 3235, Jerusalem 91031, Israel, 3 Prince Henry's Institute of Medical Research and 4 Department of Obstetrics and Gynaecology, Monash Medical Centre, Melbourne, Victoria, Australia
BACKGROUND: In a previous study we have found that in normal ovulatory women, serum inhibin B levels on days 4–6 of FSH administration correlated with the number of oocytes retrieved. In the current study we examined the significance of earlier inhibin B measurements in predicting the oocyte number, in both normal and low responders. METHODS: Study A consisted of 19 patients undergoing their first IVF cycle (n = 10) or had a normal response (
6 oocytes retrieved, n = 9), while study B consisted of 15 patients with a previous low ovarian response (
5 oocytes retrieved). All patients had day 3 FSH levels <10 IU/l. After pituitary suppression, 300 (study A) or 600 IU (study B) of pure FSH was administered daily. Serum FSH, inhibin A, inhibin B and estradiol (E2) were determined prior to and every 1–2 days throughout FSH treatment. RESULTS: Study A: oocyte number between 4 and 14 correlated significantly with serum inhibin B levels on all days of FSH treatment, and with inhibin A and E2 late during treatment. No correlation was found between inhibin B and when oocyte number was >16. Study B: oocyte number correlated significantly with inhibin B and inhibin A on all days of FSH treatment, even on day 2 (r = 0.90, P < 0.001 and r = 0.65, P < 0.05 for inhibin B and A respectively). No significant correlation was found with E2 levels. In both studies, all patients with inhibin B >100 pg/ml on treatment day 2 had >6 oocytes. CONCLUSIONS: Our data suggest that serum inhibin B measured early during FSH stimulation may indicate whether sufficient oocytes will be retrieved, in both normal and low responders. Serum inhibin B measured during early FSH treatment may be of predictive value in monitoring ovarian stimulation treatment for IVF.
Key words: inhibin A/inhibin B/IVF/low responders/oocyte number
5 To whom correspondence should be addressed at: IVF Unit, Shaare-Zedek Medical Center, Ben-Gurion University, P.O.Box 3235, Jerusalem 91031, Israel. E-mail: gevat{at}szmc.org.il
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