Human Reproduction, Vol. 17, No. 9, 2428-2434,
September 2002
© 2002 European Society of Human Reproduction and Embryology
Surface vascularization and endometrial appearance in women with menorrhagia or using levonorgestrel contraceptive implants. Implications for the mechanisms of breakthrough bleeding
1 Department of Obstetrics and Gynaecology, University of Western Australia King Edward Memorial Hospital, 374 Bagot Road, Subiaco, WA 6008 and 2 Sydney Centre for Reproductive Health Research, Department of Obstetrics and Gynaecology, University of Sydney, NSW 2006, Australia
BACKGROUND: Women using progestogen-only contraceptives are commonly troubled by irregular bleeding. Endometrial vessel breakdown and repair is thought to be locally regulated under the indirect influence of sex steroids. Most information about endometrial vessels is derived from blind biopsies taken in an outpatient setting. Hysteroscopy allows in-vivo observation of the whole endometrial surface, including vessel morphology, distribution and areas of bleeding, as well as information about non-vascular structures that may not be accessible from biopsies. METHODS: Hysteroscopies were performed on 34 women using the levonorgestrel contraceptive implant system (NorplantTM) and in a comparison group of 20 women complaining of menorrhagia due to ovulatory dysfunctional bleeding. The images were captured and vascular appearances assessed using image analysis. RESULTS: The percentage of the superficial endometrium covered with blood vessels was found to be significantly greater in Norplant users compared with the comparison group (P = 0.0006). More superficial vessels were seen in those with recent frequent or prolonged bleeding and spotting (P < 0.0001). In Norplant users, but not in the comparison group, superficial vascular distribution was predominantly patchy (P < 0.0001). Unusual vascular appearances classified as `neovascular' (P < 0.0001) and `mosaic' (P < 0.0001) patterns were commonly seen in Norplant users but not in the comparison group. The hysteroscopic appearance of the endometrial epithelium, glands and stroma also differed between Norplant users and women with menorrhagia. Apparent shedding of the superficial endometrium was commonly seen by hysteroscopy in Norplant users during a bleeding episode (P < 0.0001). Prominent gland openings with thick mucus were commonly seen in Norplant users and small sessile polyps were seen in six cases. CONCLUSIONS: These hysteroscopic observations provide further evidence that exposure to progestogens alters the superficial endometrial vasculature and may interfere with angiogenesis.
Key words: breakthrough bleeding/endometrium/hysteroscopy/Norplant
3 To whom correspondence should be addressed. E-mail: mhickey{at}obsgyn.uwa.edu.au
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  N. B Morison, T. J Kaitu'u-Lino, I. S Fraser, and L. A Salamonsen Stimulation of epithelial repair is a likely mechanism for the action of mifepristone in reducing duration of bleeding in users of progestogen-only contraceptives Reproduction, August 1, 2008; 136(2): 267 - 274. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
N. B Morison, J. Zhang, T. J Kaitu'u-Lino, I. S Fraser, and L. A Salamonsen The long-term actions of etonogestrel and levonorgestrel on decidualized and non-decidualized endometrium in a mouse model mimic some effects of progestogen-only contraceptives in women Reproduction, January 1, 2007; 133(1): 309 - 321. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. N. Jabbour, R. W. Kelly, H. M. Fraser, and H. O. D. Critchley Endocrine Regulation of Menstruation Endocr. Rev., February 1, 2006; 27(1): 17 - 46. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 P.A.W. Rogers, F. Martinez, J.E. Girling, F. Lederman, L. Cann, E. Farrell, F. Tresserra, and N. Patel Influence of different hormonal regimens on endometrial microvascular density and VEGF expression in women suffering from breakthrough bleeding Hum. Reprod., December 1, 2005; 20(12): 3341 - 3347. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 E. A. Pritts, I. P. Ryan, M. D. Mueller, D. I. Lebovic, J. L. Shifren, C. J. Zaloudek, A. P. Korn, P. D. Darney, and R. N. Taylor Angiogenic Effects of Norplant Contraception on Endometrial Histology and Uterine Bleeding J. Clin. Endocrinol. Metab., April 1, 2005; 90(4): 2142 - 2147. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.H. Shaamash and M.M. Zakhari Increased serum levels of nitric oxide metabolites among users: a possible role in progestin-induced bleeding Hum. Reprod., January 1, 2005; 20(1): 302 - 306. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B.A. Roopa, A. Loganath, and K. Singh The effect of a levonorgestrel-releasing intrauterine system on angiogenic growth factors in the endometrium Hum. Reprod., September 1, 2003; 18(9): 1809 - 1819. [Abstract] [Full Text] [PDF]
|
|