Human Reproduction, Vol. 18, No. 1, 152-166,
January 2003
© 2003 European Society of Human Reproduction and Embryology
Expression of erythropoietin and erythropoietin receptor in peritoneal endometriosis
1 Department of Obstetrics & Gynecology, Tohoku University School of Medicine, 1–1, Seiryo-machi, Aoba-ku, Sendai, 980–8574, Japan and 2 Department of Gynecology, Polyclinique de l’Hotel-Dieu, 13, boulevard Charles-De-Gaulle, 63003 Clermont-Ferrand Cedex 1, France 3 Present address: Department of Gynecology, Polyclinique de l’Hotel-Dieu, 13, boulevard Charles-De-Gaulle, 63003 Clermont-Ferrand Cedex 1, France 4 To whom correspondence should be addressed at: Department of Gynecology, Polyclinique de l’Hôtel-Dieu, 13, boulevard Charles-De-Gaulle, 63003 Clermont-Ferrand Cedex 1, France. e-mail: SachikoMA{at}aol.com
BACKGROUND: Recent studies have indicated new physiological roles for erythropoietin (Epo) unrelated to erythropoiesis. We previously demonstrated that the Epo concentrations in peritoneal fluid from patients with stage I endometriosis were significantly higher than those with stages II, III and IV of the disease. Therefore, we hypothesized that Epo may play a role in the pathogenesis of endometriosis, particularly during the early stages of the disease. METHOD: We investigated the localization of Epo and the Epo receptor (Epo-R) in peritoneal endometriosis and eutopic endometrium, using immunohistochemistry. RESULTS: We detected Epo and Epo-R localized within glandular epithelial cells in both peritoneal endometriosis and eutopic endometrium. There was no significant difference in Epo expression between red and black peritoneal lesions, whereas Epo-R expression was significantly lower in black peritoneal lesions when compared to red lesions. Epo and Epo-R expression levels within red peritoneal lesions were comparable to those of eutopic endometrium from patients with endometriosis. CONCLUSION: The present findings suggest that Epo may play a role in the pathophysiology of endometriosis.
Key words: black endometriotic lesions/erythropoietin/erythropoietin-receptor/red endometriotic lesions
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