Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (14)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Hreinsson, J.
Right arrow Articles by Fridström, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Hreinsson, J.
Right arrow Articles by Fridström, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 18, No. 10, 2131-2136, October 2003
© 2003 European Society of Human Reproduction and Embryology

Recombinant LH is equally effective as recombinant hCG in promoting oocyte maturation in a clinical in-vitro maturation programme: a randomized study

Julius Hreinsson1,3, Björn Rosenlund1, Barbro Fridén1, Lev Levkov1, Ingvar Ek1, Anne-Maria Suikkari2, Outi Hovatta1 and Margareta Fridström1

1 Karolinska Institutet, Department of Obstetrics and Gynaecology, Huddinge University Hospital, Stockholm, Sweden and 2 The Family Federation of Finland, Kalevagatan 16, Helsinki, Finland

3 To whom correspondence should be addressed at: Karolinska Institutet, Department of Obstetrics and Gynaecology, Huddinge University Hospital, S-141 86 Stockholm, Sweden. e-mail: Julius.Hreinsson{at}hs.se

BACKGROUND: Fertilization treatment using oocytes matured in vitro from pre-ovulatory follicles has many potential applications. It minimizes the risk of severe ovarian hyperstimulation and is an alternative for women with polycystic ovary syndrome who may have problems regarding stimulation for IVF. In-vitro maturation (IVM) may prove important for subjects needing fertility preservation, and also provides information about the final stages of oocyte maturation. METHODS: From a randomized study of 73 women in an IVF programme, 36 subjects with 228 oocytes were allocated for oocyte maturation in culture medium with recombinant hCG, and 37 subjects with 256 oocytes for maturation with recombinant LH. The primary outcome was the rate of nuclear maturation of oocytes to metaphase II. During the same period, 32 women outside the study underwent 38 individually tailored IVM treatments. RESULTS: The oocyte maturation rate was 54.8% with hCG and 55.9% with LH; fertilization and cleavage rates were not significantly different. Three pregnancies were achieved in the hCG group and one in the LH group. Seven pregnancies (22.6% per embryo transfer) were achieved in the parallel group. CONCLUSIONS: Recombinant hCG or LH are equally effective in promoting oocyte maturation in a clinical IVM programme.

Key words: cryopreservation/culture/maturation in vitro/oocyte/ovarian follicles


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
B. Friden, J. Hreinsson, and O. Hovatta
Birth of a healthy infant after in vitro oocyte maturation and ICSI in a woman with diminished ovarian response: Case report
Hum. Reprod., September 1, 2005; 20(9): 2556 - 2558.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
H. Al-Inany, M. A. Aboulghar, R. T. Mansour, and M. Proctor
Recombinant versus urinary gonadotrophins for triggering ovulation in assisted conception
Hum. Reprod., August 1, 2005; 20(8): 2061 - 2073.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
Z.J. Chen, M. Li, Y. Li, L.X. Zhao, R. Tang, Y. Sheng, X. Gao, C.H. Chang, and H.L. Feng
Effects of sucrose concentration on the developmental potential of human frozen-thawed oocytes at different stages of maturity
Hum. Reprod., October 1, 2004; 19(10): 2345 - 2349.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.