Human Reproduction, Vol. 18, No. 11, 2478-2484,
November 2003
© 2003 European Society of Human Reproduction and Embryology
Infertility and preterm delivery, birthweight, and Caesarean section: a study within the Danish National Birth Cohort
1 Danish Epidemiology Science Centre, University of Århus, Denmark and 2 Epidemiology Branch, NIEHS, Research Triangle Park, NC, USA
3 To whom correspondence should be addressed at: Danish Epidemiology Science Centre, Department of Epidemiology and Social Medicine, Building 260, University of Århus, Vennelyst Boulevard 6, 8000 Århus C, Denmark. e-mail: ob{at}soci.au.dk
BACKGROUND: More than 10% of babies are born to couples taking >1 year to conceive (a common definition of infertility). Some evidence indicates that such pregnancies are at increased risk of preterm delivery and other adverse birth outcomes, but the problem has rarely been addressed in large, longitudinal studies enrolling couples irrespective of infertility treatment. METHODS: We used data from the Danish National Birth Cohort: 55 906 singleton live births from women who reported their waiting time to pregnancy (TTP) and other covariates in an interview during the 2nd trimester of pregnancy. RESULTS: A TTP >1 year was associated with an increased risk of all outcomes studied, including preterm birth [odds ratios and 95% confidence intervals were 1.5 (1.2, 1.8) among primiparas and 1.9 (1.5, 2.4) among multiparas]. Odds ratios for preterm remained elevated after adjustment for covariates. Among couples with a TTP >1 year, infertility treatment was associated with added risk only among multiparas. CONCLUSION: Infertile women are at higher risk of adverse birth outcomes even if they conceive without treatment. With >10% of babies born to infertile couples, it is important to consider this group as potentially high risk when providing prenatal care.
Key words: birthweight/Caesarean section/infertility/preterm delivery/time to pregnancy
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  C. R. Weinberg and M. Shi The Genetics of Preterm Birth: Using What We Know to Design Better Association Studies Am. J. Epidemiol., December 1, 2009; 170(11): 1373 - 1381. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 W. Shih, D.D. Rushford, H. Bourne, C. Garrett, J.C. McBain, D.L. Healy, and H.W.G. Baker Factors affecting low birthweight after assisted reproduction technology: difference between transfer of fresh and cryopreserved embryos suggests an adverse effect of oocyte collection Hum. Reprod., July 1, 2008; 23(7): 1644 - 1653. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. H. Ramlau-Hansen, A. M. Thulstrup, J. Olsen, and J. P. Bonde Parental Subfecundity and Risk of Decreased Semen Quality in the Male Offspring: A Follow-up Study Am. J. Epidemiol., June 15, 2008; 167(12): 1458 - 1464. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
X.-K. Chen, S. W. Wen, D. Krewski, N. Fleming, Q. Yang, and M. C. Walker Paternal age and adverse birth outcomes: teenager or 40+, who is at risk? Hum. Reprod., June 1, 2008; 23(6): 1290 - 1296. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. M. Chambers, M. G. Chapman, N. Grayson, M. Shanahan, and E. A. Sullivan Babies born after ART treatment cost more than non-ART babies: a cost analysis of inpatient birth-admission costs of singleton and multiple gestation pregnancies Hum. Reprod., December 1, 2007; 22(12): 3108 - 3115. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pinborg, O. Lidegaard, N. la Cour Freiesleben, and A. N. Andersen Vanishing twins: a predictor of small-for-gestational age in IVF singletons Hum. Reprod., October 1, 2007; 22(10): 2707 - 2714. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. Koivurova, A.-L. Hartikainen, M. Gissler, E. Hemminki, and M.-R. Jarvelin Post-neonatal hospitalization and health care costs among IVF children: a 7-year follow-up study Hum. Reprod., August 1, 2007; 22(8): 2136 - 2141. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 S. E M Lewis Is sperm evaluation useful in predicting human fertility? Reproduction, July 1, 2007; 134(1): 31 - 40. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Luke and M. B. Brown Elevated risks of pregnancy complications and adverse outcomes with increasing maternal age Hum. Reprod., May 1, 2007; 22(5): 1264 - 1272. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Poikkeus, M. Gissler, L. Unkila-Kallio, C. Hyden-Granskog, and A. Tiitinen Obstetric and neonatal outcome after single embryo transfer Hum. Reprod., April 1, 2007; 22(4): 1073 - 1079. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Sun, M. Vestergaard, J. Christensen, J. L. Zhu, B. H. Bech, and J. Olsen Epilepsy and febrile seizures in children of treated and untreated subfertile couples Hum. Reprod., January 1, 2007; 22(1): 215 - 220. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. Klemetti, T. Sevon, M. Gissler, and E. Hemminki Health of Children Born as a Result of In Vitro Fertilization Pediatrics, November 1, 2006; 118(5): 1819 - 1827. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. De Sutter, I. Delbaere, J. Gerris, H. Verstraelen, S. Goetgeluk, J. Van der Elst, M. Temmerman, and M. Dhont Birthweight of singletons after assisted reproduction is higher after single- than after double-embryo transfer Hum. Reprod., October 1, 2006; 21(10): 2633 - 2637. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Hvidtjorn, J. Grove, D. E. Schendel, M. Vaeth, E. Ernst, L. F. Nielsen, and P. Thorsen Cerebral Palsy Among Children Born After in Vitro Fertilization: The Role of Preterm Delivery--A Population-Based, Cohort Study Pediatrics, August 1, 2006; 118(2): 475 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. De Sutter, J. Bontinck, V. Schutysers, J. Van der Elst, J. Gerris, and M. Dhont First-trimester bleeding and pregnancy outcome in singletons after assisted reproduction Hum. Reprod., July 1, 2006; 21(7): 1907 - 1911. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 H. Verstraelen, S. Goetgeluk, C. Derom, S. Vansteelandt, R. Derom, E. Goetghebeur, and M. Temmerman Preterm birth in twins after subfertility treatment: population based cohort study BMJ, November 19, 2005; 331(7526): 1173. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Pinborg IVF/ICSI twin pregnancies: risks and prevention Hum. Reprod. Update, November 1, 2005; 11(6): 575 - 593. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. L. Zhu, K. M. Madsen, M. Vestergaard, A. V. Olesen, O. Basso, and J. Olsen Paternal age and congenital malformations Hum. Reprod., November 1, 2005; 20(11): 3173 - 3177. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pinborg, O. Lidegaard, N. la Cour Freiesleben, and A. N. Andersen Consequences of vanishing twins in IVF/ICSI pregnancies Hum. Reprod., October 1, 2005; 20(10): 2821 - 2829. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
B. Horsthemke and M. Ludwig Assisted reproduction: the epigenetic perspective Hum. Reprod. Update, September 1, 2005; 11(5): 473 - 482. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
O. Basso and J. Olsen Subfecundity and neonatal mortality: longitudinal study within the Danish national birth cohort BMJ, February 19, 2005; 330(7488): 393 - 394. [Full Text] [PDF]
|
|
|
|
|
|
S. Koivurova, A.-L. Hartikainen, M. Gissler, E. Hemminki, R. Klemetti, and M.-R. Jarvelin Health care costs resulting from IVF: prenatal and neonatal periods Hum. Reprod., December 1, 2004; 19(12): 2798 - 2805. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Pinborg, A. Loft, S. Rasmussen, and A. Nyboe Andersen Hospital care utilization of IVF/ICSI twins followed until 2-7 years of age: a controlled Danish national cohort study Hum. Reprod., November 1, 2004; 19(11): 2529 - 2536. [Abstract] [Full Text] [PDF]
|
|