Human Reproduction, Vol. 18, No. 12, 2508-2511,
December 2003
© 2003 European Society of Human Reproduction and Embryology
Epigenetic risks related to assisted reproductive technologies: Epigenetics, imprinting, ART and icebergs?
1 Section of Medical and Molecular Genetics, Division of Reproductive and Child Health, University of Birmingham Medical School, Birmingham and West Midlands Regional Genetics Service, Birmingham Women’s Hospital, Edgbaston, Birmingham and 2 Assisted Conception Unit, Birmingham Women’s Hospital, Edgbaston, Birmingham and Division of Reproductive and Child Health, University of Birmingham Medical School, Birmingham, UK
3 To whom correspondence should be addressed at: Section of Medical and Molecular Genetics, Department of Paediatrics and Child Health, University of Birmingham, The Medical School, Edgbaston, Birmingham B15 2TT, UK. e-mail: E.R.Maher{at}bham.ac.uk
Recently, a series of case reports and small studies has suggested that births involving assisted reproductive technology (ART) may have an increased risk of imprinting disorders such as Beckwith–Wiedemann syndrome and Angelman syndrome. Herein, the significance and implications of these findings are discussed. It is speculated that, although such imprinting disorders may be shown to be only rare complications of ART, epigenetic errors might account for a much wider spectrum of ART-related complications than is recognized currently. Addressing these questions should be a priority for research on cohorts of ART children.
Key words: ART/epigenetics/imprinting/safety
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