Human Reproduction, Vol. 18, No. 12, 2595-2598,
December 2003
© 2003 European Society of Human Reproduction and Embryology
Women with endometriosis have increased levels of placental growth factor in the peritoneal fluid compared with women with cystadenomas
Department of Obstetrics and Gynecology, Nagoya City University, Graduate School of Medicine, 1 Kawasumi, Mizuho-ku, Mizuho-cho, Nagoya 467-8601, Japan
1 To whom correspondence should be addressed. e-mail: og.n.suz{at}med.nagoya-cu.ac.jp
BACKGROUND: To assess the release of placental growth factor (PlGF) into peritoneal fluid in women with and without endometriosis, we measured its concentration with reference to disease stage, the presence of red endometriotic lesions and the phase of menstrual cycle. METHODS: Surgery was scheduled in the proliferative or secretory phase of the menstrual cycle for 59 women with (n = 35) or without (n = 24) endometriosis. The latter group comprised women undergoing surgery for ovarian cystadenomas. PlGF concentrations in the peritoneal fluid were measured using an enzyme-linked immunosorbent assay. RESULTS: PlGF concentration in the peritoneal fluid was markedly elevated in the endometriosis patients (median 189 pg/ml, interquartile range 84–475 pg/ml) as compared with the controls (88 pg/ml, 41–213 pg/ml; P < 0.001), especially in women with red lesions. Significantly greater values during the secretory phase of the menstrual cycle as compared with the proliferative phase were observed in both the control (cystadenoma) group (P < 0.05) and the endometriosis group (P < 0.001). CONCLUSIONS: Our findings suggest that production of PlGF is sensitive to the cyclic changes in ovarian steroids and may contribute to the pathogenesis of endometriosis, especially that of red lesions, by promoting neovascularization.
Key words: angiogenesis/menstrual cycle/neovascularization/PlGF/red lesions
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  J. Gilabert-Estelles, L.A. Ramon, F. Espana, J. Gilabert, V. Vila, E. Reganon, R. Castello, M. Chirivella, and A. Estelles Expression of angiogenic factors in endometriosis: relationship to fibrinolytic and metalloproteinase systems Hum. Reprod., August 1, 2007; 22(8): 2120 - 2127. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. P. Ponnampalam, G. C. Weston, A. C. Trajstman, B. Susil, and P. A.W. Rogers Molecular classification of human endometrial cycle stages by transcriptional profiling Mol. Hum. Reprod., December 1, 2004; 10(12): 879 - 893. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. Print, R. Valtola, A. Evans, K. Lessan, S. Malik, and S. Smith Soluble factors from human endometrium promote angiogenesis and regulate the endothelial cell transcriptome Hum. Reprod., October 1, 2004; 19(10): 2356 - 2366. [Abstract] [Full Text] [PDF]
|
|