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Human Reproduction, Vol. 18, No. 2, 267-270, February 2003
© 2003 European Society of Human Reproduction and Embryology

A polymorphism of the interleukin-6 gene promoter and idiopathic recurrent miscarriage

G. Unfried1,4, S. Böcskör1, G. Endler3, F. Nagele1, J.C. Huber1 and C.B. Tempfer2

1 Department of Gynecologic Endocrinology and Reproductive Medicine, 2 Department of Obstetrics and Gynecology, and 3 Department of Laboratory Medicine, University of Vienna School of Medicine, Vienna, Austria

4 To whom correspondence should be addressed at: Department of Gynecologic Endocrinology and Reproductive Medicine, University of Vienna School of Medicine, Waehringer Guertel 18–20, A-1090 Vienna, Austria. e-mail: gertrud.unfried{at}akh-wien.ac.at

BACKGROUND: Cytokines have been described to play a major role in the pathogenesis of idiopathic recurrent miscarriage (IRM). We investigated the association between IRM and a polymorphism of the interleukin-6 (IL-6) gene and IL-6 serum levels. METHODS: In a prospective case–control study, we studied 161 women with IRM and 124 healthy controls. Peripheral venous puncture, DNA extraction and PCR were employed to genotype women for the presence of a polymorphism at position –174 in the promoter region of IL-6. Serum IL-6 levels were assessed by a commercially available ELISA. RESULTS: Allele frequencies among women with IRM and controls were 63.4 and 58.1% respectively for allele G (wild type), and 36.6 and 41.9% respectively for allele C (mutant). No association between allele C and the occurrence of IRM was found (odds ratio 0.8; 95% confidence interval = 0.57–1.12; P = NS). IL-6 serum levels were not significantly different between genotypes and between the study and control groups. CONCLUSIONS: This is the first report on an IL-6 polymorphism in IRM. Although known to alter IL-6 expression, the IL-6 polymorphism investigated was not associated with IRM and alterations in IL-6 serum levels in a Middle-European Caucasian population.

Key words: cytokines/idiopathic recurrent miscarriage/interleukin-6/polymorphism/risk factor


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