Human Reproduction, Vol. 18, No. 2, 323-327,
February 2003
© 2003 European Society of Human Reproduction and Embryology
Serum anti-Müllerian hormone is more strongly related to ovarian follicular status than serum inhibin B, estradiol, FSH and LH on day 3
Departments of 1 Obstetrics and Gynecology and Reproductive Medicine, Clamart, France, and 2 Biochemistry and 3 Hormonology, Paris and Clamart, France
4 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology and Reproductive Medicine, Hôpital Antoine Béclère, 157, rue de la Porte de Trivaux, 92141, Clamart, France. e-mail: renato.fanchin{at}abc.ap-hop-paris.fr
BACKGROUND: The study aim was to compare the relationship between serum anti-Müllerian hormone (AMH) levels and other markers of ovarian function with early antral follicle count on day 3. METHODS: A total of 75 infertile women was studied prospectively. On cycle day 3, serum levels of AMH, inhibin B, estradiol (E2), FSH and LH levels were measured, and the number of early antral follicles (2–10 mm in diameter) estimated at ultrasound scanning to compare the strengths of hormonal–follicular correlations. RESULTS: Median (range) serum levels of AMH, inhibin B, E2, FSH and LH were 1.39 ng/ml (0.24–6.40), 90 (16–182) pg/ml, 31 (15–111) pg/ml, 7.0 (2.9–19.3) mIU/ml and 4.7 (1.2–11.7) mIU/ml respectively, and follicular count was 12 (1–35). Serum AMH levels were more strongly correlated (P < 0.001) with follicular count (r = 0.74, P < 0.0001) than were serum levels of inhibin B (r = 0.29, P < 0.001), E2 (r = –0.08, P = NS), FSH (r = –0.29, P < 0.001) and LH (r = 0.05, P = NS). CONCLUSIONS: Serum AMH levels were more robustly correlated with the number of early antral follicles than inhibin B, E2, FSH and LH on cycle day 3. This suggests that AMH may reflect ovarian follicular status better than the usual hormone markers.
Key words: anti-Müllerian hormone/antral follicles/endocrine profile/Müllerian-inhibiting substance (MIS)/ovarian reserve
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