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Human Reproduction, Vol. 18, No. 3, 473-475, March 2003
© 2003 European Society of Human Reproduction and Embryology

Reproductive semi-cloning respecting biparental origin

Reconstitution of gametes for assisted reproduction

U. Eichenlaub-Ritter

Universitat Bielefeld, Fakultat Biologie, Gentechnologie/Mikrobiologie, Postfach 100131, D-33501, Bielefeld, Germany. E-mail: eiri@biologie.uni-bielefeld.de

There are basically two major problems in the genesis of ‘cloned’ gametes in mammals, which have not been addressed in the original debate article. There is no adequate discussion on the mechanisms providing for high fidelity of chromosome segregation in mitosis and meiosis, and for proper imprinting in construction of ‘reconstituted gametes’. The original debate article is uncritical with respect to the currently insufficient database and the incomplete documentation of results.

Key words: assisted reproduction/cloning/gamete reconstitution/haploidization


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