Human Reproduction, Vol. 18, No. 3, 544-549,
March 2003
© 2003 European Society of Human Reproduction and Embryology
An association of IgG anti-laminin-1 autoantibodies with endometriosis in infertile patients
1 Department of Cell Chemistry, Okayama University Graduate School of Medicine and Dentistry, 2–5-1 Shikata-cho, Okayama 700–8558, 2 Department of Obstetrics and Gynecology, Nagoya City University Medical School, Nagoya 467–8601, 3 Division of Bioscience, Graduate School of Environmental Earth Science, Hokkaido University, Sapporo 060–0810, 4 Department of Obstetrics and Gynecology, Okayama University Medical School, Okayama 700–8558, 5 Department of Obstetrics and Gynecology II, Nagoya City Johsai Hospital, Nagoya 453–0815, Japan and 6 Department of Medicine ‘B’ and the Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer 52621, Israel
7 To whom correspondence should be addressed e-mail: eijimatu{at}md.okayama-u.ac.jp
BACKGROUND: Laminin-1, a multifunctional glycoprotein of the basement membrane, is thought to be important in embryogenesis, embryonic implantation, and placentation. We recently showed that serum IgG anti-laminin-1 autoantibodies (auto-Abs) are associated with recurrent first-trimester miscarriages. The present study assessed the clinical significance of anti-laminin-1 Abs with infertility, accompanied with or without endometriosis. METHODS: Sixty-eight infertile patients who underwent laparoscopy or laparotomy and 39 healthy non-pregnant women were tested for IgG anti-laminin-1 Abs. The association between the Abs and endometriosis was analysed. The presence of laminin-1 mRNA was detected in endometriotic lesions. RESULTS: Twenty infertile patients were positive for anti-laminin-1 Abs. The Ab levels in those patients were significantly higher than those in healthy non-pregnant women (P = 0.0005). The presence of the Abs was significantly associated with endometriosis in those patients (P = 0.0096). The Abs recognized a particular domain, i.e., the laminin-
1 chain G domain. mRNA encoding laminin-1, -
1, and -
1 chains was expressed in 90% of endometriotic lesions. CONCLUSIONS: IgG anti-laminin-1 Abs were significantly associated with endometriosis in infertile patients. The Abs might be clinically important in the development of autoimmune-mediated reproductive failures and the assessment of the Abs may provide a novel non-invasive diagnosis of endometriosis.
Key words: anti-laminin-1 autoantibody/endometriosis/infertility/miscarriage
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