Human Reproduction, Vol. 18, No. 3, 593-597,
March 2003
© 2003 European Society of Human Reproduction and Embryology
Peritoneal fluid concentrations of interleukin-8 in patients with endometriosis depend on the severity of the disorder and are higher in the luteal phase
1 Human Reproduction Unit, Department of Obstetrics and Gynaecology and 2 Lisbon University Haematology and Immunology Centre, Hospital de Santa Maria, Av. Prof. Egas Moniz, Lisboa, Portugal
3 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Hospital de Santa Maria, Av. Egas Moniz, 1649-028 Lisboa, Portugal. e-mail: calhazjorge{at}mail.telepac.pt
BACKGROUND: Previous evaluations of the relationship between the concentrations of interleukin-8 (IL-8) in the peritoneal fluid and endometriosis led to non-consistent results. Our purpose was to investigate the correlation of the concentrations of IL-8 in the peritoneal fluid with the stage of endometriosis, the presence of red lesions and the phase of the menstrual cycle. METHODS: Ninety-two patients with infertility (n = 87) or undergoing sterilization (n = 5) had peritoneal fluid samples collected at laparoscopy. IL-8 determinations were performed using an enzyme-linked immunosorbent assay. RESULTS: The concentrations of IL-8 in the peritoneal fluid of the 68 women with endometriosis were not significantly different from those of the 24 controls. Patients with moderate/severe stages had IL-8 significantly higher than controls (P = 0.008) and marginally higher than patients with minimal/mild endometriosis (P = 0.053). Concentrations of IL-8 were significantly higher in patients than in controls in the luteal phase. Red lesions were associated with significantly increased levels of peritoneal fluid IL-8 only in the luteal phase. CONCLUSIONS: Our findings reinforce the importance of IL-8 in the pathogenesis of endometriosis.
Key words: endometriosis/IL-8/luteal phase/peritoneal fluid/peritoneal red lesions
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