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Human Reproduction, Vol. 18, No. 5, 915-924, May 2003
© 2003 European Society of Human Reproduction and Embryology

Immune infertility: towards a better understanding of sperm (auto)-immunity

The value of proteomic analysis

Claudia Bohring and Walter Krause1

Department of Andrology and Venerology, University Hospital, Philipp University, D-35033 Marburg, Germany

1 To whom correspondence should be addressed. e-mail: krause{at}mailer.uni-marburg.de

Antisperm antibodies (ASA) in the male cause an autoimmune disease ‘immune infertility’. It has to be clarified whether each antibody binding to an antigen, which is identified on the sperm surface, also influences sperm function. In the past, the clinical interest in ASA was hampered by the fact that a standardized assay for the detection of ASA was lacking. There are several methods to characterize the cognate antigens of ASA. In the following article, reports from the recent literature of immunologically characterized sperm proteins—as cognate antigens of naturally occurring ASA or of artificially produced antibodies—will be quoted with respect to different sperm functions. As a practical consequence of the research on ASA-related sperm proteomics, those ASA that decrease male fertility by inhibiting sperm functions essential for fertilization will be identified.

Key words: antisperm antibodies/autoimmunity/proteomics/sperm antigens


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