Skip Navigation

This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (24)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Bohring, C.
Right arrow Articles by Krause, W.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Bohring, C.
Right arrow Articles by Krause, W.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction, Vol. 18, No. 5, 915-924, May 2003
© 2003 European Society of Human Reproduction and Embryology

Immune infertility: towards a better understanding of sperm (auto)-immunity

The value of proteomic analysis

Claudia Bohring and Walter Krause1

Department of Andrology and Venerology, University Hospital, Philipp University, D-35033 Marburg, Germany

1 To whom correspondence should be addressed. e-mail: krause{at}mailer.uni-marburg.de

Antisperm antibodies (ASA) in the male cause an autoimmune disease ‘immune infertility’. It has to be clarified whether each antibody binding to an antigen, which is identified on the sperm surface, also influences sperm function. In the past, the clinical interest in ASA was hampered by the fact that a standardized assay for the detection of ASA was lacking. There are several methods to characterize the cognate antigens of ASA. In the following article, reports from the recent literature of immunologically characterized sperm proteins—as cognate antigens of naturally occurring ASA or of artificially produced antibodies—will be quoted with respect to different sperm functions. As a practical consequence of the research on ASA-related sperm proteomics, those ASA that decrease male fertility by inhibiting sperm functions essential for fertilization will be identified.

Key words: antisperm antibodies/autoimmunity/proteomics/sperm antigens


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
A.S. Samuel and R.K. Naz
Isolation of human single chain variable fragment antibodies against specific sperm antigens for immunocontraceptive development
Hum. Reprod., June 1, 2008; 23(6): 1324 - 1337.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J. Capkova, F. Elzeinova, and P. Novak
Increased expression of secretory actin-binding protein on human spermatozoa is associated with poor semen quality
Hum. Reprod., May 1, 2007; 22(5): 1396 - 1404.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
K. L. Pixton, E. D. Deeks, F. M. Flesch, F. L.C. Moseley, L. Bjorndahl, P. R. Ashton, C. L.R. Barratt, and I. A. Brewis
Sperm proteome mapping of a patient who experienced failed fertilization at IVF reveals altered expression of at least 20 proteins compared with fertile donors: Case report
Hum. Reprod., June 1, 2004; 19(6): 1438 - 1447.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
G. N. Clarke
Sperm autoimmunity
Hum. Reprod., May 1, 2004; 19(5): 1235 - 1235.
[Full Text] [PDF]

Home page
 Hum ReprodHome page
J. H. Check
Present options for treating sperm autoimmunity before proteomic analysis is available
Hum. Reprod., November 1, 2003; 18(11): 2489 - 2490.
[Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.