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Human Reproduction, Vol. 18, No. 6, 1140-1141, June 2003
© 2003 European Society of Human Reproduction and Embryology

Prediction of ovarian hyperstimulation syndrome (OHSS)

Estradiol level has an important role in the prediction of OHSS

Mohamed Aboulghar1

Department of Obstetrics and Gynecology, Cairo University and the Egyptian IVF-ET Center, Maadi, Cairo, Egypt

1 To whom correspondence should be addressed at: 3, street no. 161 Hadayek El Maadi, Maadi, Cairo 11431 Egypt. e-mail: ghar{at}link.net

The cascade of events that leads to the development of ovarian hyperstimulation syndrome (OHSS) is almost always accompanied by elevated estradiol (E2) levels. The role of estrogen level in OHSS has not been confirmed; however, it was shown repeatedly in the literature that elevated levels of E2 constitute a risk for OHSS. Monitoring E2 was found to be effective in reducing the incidence of OHSS. It was also reported that reducing the E2 level by coasting helps to prevent OHSS. It is believed that irrespective of the debatable role of estrogen in the pathogenesis of OHSS, there is a general agreement that E2 assay is an important marker to detect the majority of patients at risk of OHSS.

Key words: coasting/E2 level/OHSS/prediction


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