Human Reproduction, Vol. 18, No. 6, 1256-1258,
June 2003
© 2003 European Society of Human Reproduction and Embryology
The administration of the GnRH antagonist, cetrorelix, to ooctye donors simplifies oocyte donation
1 Assisted Conception Programme, Edinburgh Fertility and Reproductive Endocrine Centre, Edinburgh Royal Infirmary, Little France, 51 Little France Crescent, Edinburgh EH16 4SA, Scotland and 2 Department of Obstetrics and Gynaecology, Kent Ridge Road, National University of Singapore, Singapore
3 To whom correspondence should be addressed. e-mail: joothong{at}hotmail.com
BACKGROUND: We report our experience on the efficacy of a new regimen of the GnRH antagonist, cetrorelix, and recombinant FSH, Gonal-F, for controlled ovarian stimulation in a donor oocyte programme. METHODS AND RESULTS: Six oocyte donors were commenced on Gonal-F (150 IU) and two on Gonal-F 225 IU daily on day 4 together with cetrorelix 0.25 mg daily on day 8 until the day of administration of hCG. Six premenopausal recipients were down-regulated with intranasal Nafarelin 400 µg twice daily; two women with premature menopause did not require down-regulation for synchronization between donor and recipient cycles. The median (range) of oocytes retrieved and the median (range) fertilization rates were 7 (3–13) and 50% (0–71%) respectively. With the exception of a recipient who had failed fertilization, seven recipients had two embryos transferred. The median (range) number of days of ovarian stimulation, cetrorelix administration and number of Gonal-F ampoules administered for ovarian stimulation were 9 (7–12) days, 5 (3–8) and 18 (14–24) respectively. The clinical pregnancy rate per cycle was 50% (4/8) and one of the latter women miscarried at eight weeks gestation. Three women (37.3%) had full term deliveries. CONCLUSION: This preliminary study has shown that using a combination of cetrorelix and Gonal-F resulted in a high pregnancy rate, reduced the duration of treatment for the donor and simplified oocyte donation.
Key words: cetrorelix/donor/FSH/oocyte/recombinant
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