Human Reproduction, Vol. 18, No. 7, 1523-1528,
July 2003
© 2003 European Society of Human Reproduction and Embryology
Decrease of T-helper 2 and T-cytotoxic 2 cells at implantation sites occurs in unexplained recurrent spontaneous abortion with normal chromosomal content
1 Department of Obstetrics and Gynecology, Toyama Medical and Pharmaceutical University, 2630 Sugitani, Toyama-shi, Toyama, 930-0194, 2 Department of Obstetrics and Gynecology, Nagoya City University, Nagoya-shi, Aichi, 467-8601, 3 Department of Obstetrics and Gynecology, Johsai Hospital, Nagoya-shi, Aichi, 453-0815 and 4 Research and Development Center, BML, Kawagoe-shi, Saitama, 350-1101, Japan
5 To whom correspondence should be addressed. e-mail: s30saito{at}ms.toyama-mpu.ac.jp
BACKGROUND: In normal pregnancy, predominant type 2 cytokines help maintain pregnancy, and a T-helper (Th)1 type response is associated with unexplained recurrent spontaneous abortion (RSA). However, Th2 and T-cytotoxic (Tc)2 cells have not been localized at the implantation site in RSA. METHODS: Twenty-one cases with RSA were classified into RSA with normal chromosomal content (RSA-N, n = 10) and RSA with abnormal chromosomal content (RSA-A, n = 11). As a control, we selected 15 gestational age-matched cases of induced abortion with no history of spontaneous abortion. We immunostained paraffin-embedded decidual sections for a specific Th2 and Tc2 cell marker termed ‘chemo-attractant receptor-homologous molecule expressed on Th2 cells (CRTH2)’ and T-cell markers CD3 and CD8. The numbers and percentages of Th2 (CRTH2+CD8–CD3+) and Tc2 (CRTH2+CD8+) cells were compared between the decidua basalis and decidua parietalis. RESULTS: Th2 and Tc2 cells accumulated in the decidua basalis in normal pregnancy. Accumulation of Tc2 cells and both Th2 and Tc2 cells decreased in the decidua basalis in RSA-A and RSA-N respectively. The number and percentage of Th2, and Tc2 cells in the decidua parietalis were similar in normal pregnancy, RSA-A and RSA-N. CONCLUSION: Decreased Th2 and Tc2 cells at the implantation site may contribute to RSA-N.
Key words: CRTH2/decidua implantation/recurrent spontaneous abortion/Th2
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