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Human Reproduction, Vol. 19, No. 1, 104-106, January 2004
© 2004 European Society of Human Reproduction and Embryology

The levels of C-reactive protein in women treated by IVF

Miriam Almagor1,3, Albert Hazav2 and Haim Yaffe2

1 Division of Clinical Laboratories and 2 Department of Obstetrics and Gynecology, Bikur Cholim Hospital, Jerusalem, Israel

3 To whom correspondence should be addressed at: Division of Clinical Laboratories, Bikur Cholim Hospital, 5 Strauss Street, Jerusalem 91004, Israel. e-mail: malmagor{at}bikurholim.org.il

BACKGROUND: The complex regulation of endometrial receptivity and embryo implantation involves cytokines, several of which are stimulators of the acute-phase reactant C-reactive protein (CRP). The purpose of this study was to evaluate the concentrations of serum CRP in women treated by IVF. METHODS: Seventy-two women who underwent IVF treatment were prospectively studied. The levels of serum CRP were evaluated on the following days: oocyte retrieval, embryo transfer, 5, 6 or 7 days afterwards and 12 days after embryo transfer. RESULTS: CRP levels increased from 6.8 ± 9.5 mg/l on oocyte retrieval day to 14.6 ± 12.5 mg/l on days 5–7 post-transfer (P < 0.0001). The ratios of CRP levels for transfer day/pick-up day were 1.2 in women who conceived versus 2.5 in the non-pregnant group (P = 0.01). CONCLUSION: In women treated by IVF the concentrations of CRP in blood increase significantly during the first week following oocyte retrieval. Successful outcome is associated with a relative small increment in CRP on the day of embryo transfer.

Key words: C-reactive protein/cytokine/IVF/uterine receptivity


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