Human Reproduction, Vol. 19, No. 1, 41-47,
January 2004
© 2004 European Society of Human Reproduction and Embryology
Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome (PCOS)
Correspondence to: Bart C.J.M.Fauser, Center of Reproductive Medicine, Erasmus Medical Center, 3015 GD Rotterdam, The Netherlands. e-mail: b.fauser{at}erasmusmc.nl
Since the 1990 NIH-sponsored conference on polycystic ovary syndrome (PCOS), it has become appreciated that the syndrome encompasses a broader spectrum of signs and symptoms of ovarian dysfunction than those defined by the original diagnostic criteria. The 2003 Rotterdam consensus workshop concluded that PCOS is a syndrome of ovarian dysfunction along with the cardinal features hyperandrogenism and polycystic ovary (PCO) morphology. PCOS remains a syndrome and, as such, no single diagnostic criterion (such as hyperandrogenism or PCO) is sufficient for clinical diagnosis. Its clinical manifestations may include: menstrual irregularities, signs of androgen excess, and obesity. Insulin resistance and elevated serum LH levels are also common features in PCOS. PCOS is associated with an increased risk of type 2 diabetes and cardiovascular events.
Key words: diagnostic criteria/long-term health risks/polycystic ovary syndrome/revised 2003 consensus
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G. S. Eng, R. A. Sheridan, A. Wyman, M. M.-Y. Chi, K. P. Bibee, E. S. Jungheim, and K. H. Moley AMP Kinase Activation Increases Glucose Uptake, Decreases Apoptosis, and Improves Pregnancy Outcome in Embryos Exposed to High IGF-I Concentrations Diabetes, September 1, 2007; 56(9): 2228 - 2234. [Abstract] [Full Text] [PDF]
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L. Barnard, D. Ferriday, N. Guenther, B. Strauss, A.H. Balen, and L. Dye Quality of life and psychological well being in polycystic ovary syndrome Hum. Reprod., August 1, 2007; 22(8): 2279 - 2286. [Abstract] [Full Text] [PDF]
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B. K. Tan, J. Chen, H. Lehnert, R. Kennedy, and H. S. Randeva Raised Serum, Adipocyte, and Adipose Tissue Retinol-Binding Protein 4 in Overweight Women with Polycystic Ovary Syndrome: Effects of Gonadal and Adrenal Steroids J. Clin. Endocrinol. Metab., July 1, 2007; 92(7): 2764 - 2772. [Abstract] [Full Text] [PDF]
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T. Sir-Petermann, B. Echiburu, M M. Maliqueo, N. Crisosto, F. Sanchez, C. Hitschfeld, M. Carcamo, P. Amigo, and F. Perez-Bravo Serum adiponectin and lipid concentrations in pregnant women with polycystic ovary syndrome Hum. Reprod., July 1, 2007; 22(7): 1830 - 1836. [Abstract] [Full Text] [PDF]
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