Human Reproduction, Vol. 19, No. 1, 54-58,
January 2004
© 2004 European Society of Human Reproduction and Embryology
GnRH antagonists and mild ovarian stimulation for intrauterine insemination: a randomized study comparing different gonadotrophin dosages
1 Infertility Unit, Department of Obstetrics and Gynaecology, University of Milan and 2 Reproductive Unit, Istituto Scientifico San Raffaele, Milan, Italy
3 To whom correspondence should be addressed at: Infertility Unit, Department of Obstetrics and Gynaecology, University of Milan, Via Manfredo Fanti 6, 20122, Milan, Italy. e-mail: ragni{at}telemacus.it
BACKGROUND: The precise role of GnRH antagonists in the armamentarium of drugs for stimulation of ovulation associated with intrauterine insemination remains to be clarified. In this study, we have compared two different protocols employing GnRH antagonists in order to determine the lower effective dose of gonadotrophins to use. METHODS: Sixty-six couples with unexplained infertility or moderate male subfertility were recruited. Starting on day 3 of the cycle, 32 patients were randomized to receive 50 IU of recombinant FSH per day, whereas 34 were treated with 50 IU of recombinant FSH on alternate days. Women received the GnRH antagonist Ganirelix at a dose of 0.25 mg per day starting on the day in which a leading follicle 
14 mm in mean diameter was visualized, until HCG administration. Insemination was performed 34 h after HCG injection. RESULTS: The regimen with daily recombinant FSH was associated with a lower rate of mono-ovulation (53.3% versus 78.8%, P = 0.06) but also with a higher clinical pregnancy rate per initiated cycle (34.4% versus 5.9%, P = 0.005). CONCLUSIONS: A protocol of recombinant FSH 50 IU daily and GnRH antagonist may represent an effective and safe regimen for ovulation induction associated with intrauterine insemination.
Key words: GnRH antagonist/intrauterine insemination/ovulation induction/recombinant FSH
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Allegra, A. Marino, F. Coffaro, P. Scaglione, F. Sammartano, G. Rizza, and A. Volpes GnRH antagonist-induced inhibition of the premature LH surge increases pregnancy rates in IUI-stimulated cycles. A prospective randomized trial Hum. Reprod., January 1, 2007; 22(1): 101 - 108. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
I. Cedrin-Durnerin, N. Massin, J. Galey-Fontaine, H. Bry-Gauillard, M. Roger, N. Lahlou, and J.N. Hugues Timing of FSH administration for ovarian stimulation in normo-ovulatory women: comparison of an early or a mid follicular phase initiation of a short-term treatment Hum. Reprod., November 1, 2006; 21(11): 2941 - 2947. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.-M. Vermeylen, T. D'Hooghe, S. Debrock, L. Meeuwis, C. Meuleman, and C. Spiessens The type of catheter has no impact on the pregnancy rate after intrauterine insemination: a randomized study Hum. Reprod., September 1, 2006; 21(9): 2364 - 2367. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 B.C. Tarlatzis, B.C. Fauser, E.M. Kolibianakis, K. Diedrich, P. Devroey, and , On Behalf of the Brussels GnRH Antagonist Consen GnRH antagonists in ovarian stimulation for IVF Hum. Reprod. Update, July 1, 2006; 12(4): 333 - 340. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C.B. Lambalk, A. Leader, F. Olivennes, M.R. Fluker, A. N. Andersen, J. Ingerslev, Y. Khalaf, C. Avril, J. Belaisch-Allart, R. Roulier, et al. Treatment with the GnRH antagonist ganirelix prevents premature LH rises and luteinization in stimulated intrauterine insemination: results of a double-blind, placebo-controlled, multicentre trial Hum. Reprod., March 1, 2006; 21(3): 632 - 639. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A.J. Goverde, C.B. Lambalk, J. McDonnell, R. Schats, R. Homburg, and J.P.W. Vermeiden Further considerations on natural or mild hyperstimulation cycles for intrauterine insemination treatment: effects on pregnancy and multiple pregnancy rates Hum. Reprod., November 1, 2005; 20(11): 3141 - 3146. [Abstract] [Full Text] [PDF]
|
|