Hum. Reprod. Advance Access originally published online on July 22, 2004
Human Reproduction 2004 19(10):2216-2221; doi:10.1093/humrep/deh422
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Breast cancer risk associated with being treated for infertility: results from the French E3N cohort study
1 INSERM, équipe E3N, Institut Gustave Roussy, 39, Rue C.Desmoulins, 94805 Villejuif Cedex, France and 2 INSERM E0357, Hôpital Bichat, ci Bernard, 48, Rue H. Huchart, 75018, Paris, France
3 To whom correspondence should be addressed. Email: clavel{at}igr.fr
BACKGROUND: The use of fertility drugs (FDs) is steadily increasing in Western countries and concern has been raised as to the possible impact of fertility treatments on breast cancer risk. METHODS: We analysed this association in the French E3N study. In this prospective cohort, data on treatment against infertility, duration and time of administration were collected at entry through self-administered questionnaires. Cox regression analysis was used to estimate adjusted relative risks (RRs). RESULTS: Among the 92 555 women from the study population, 6602 women were treated for infertility. During the 10 year follow-up period, 2571 cases of primary invasive breast cancer were diagnosed (183 in treated women). Our study showed no overall significant association between breast cancer risk and treatment for infertility (RR = 0.95, confidence interval 0.82–1.11), after surgery or FDs, and whatever the type, the duration of use and the age at first use of FDs. However, infertility treatment was associated with an increased risk, of borderline significance, of breast cancer among women with a family history of breast cancer. This last result had limited statistical power. CONCLUSIONS: Our study provides evidence that treatment for infertility does not influence breast cancer risk overall. An interaction with a familial history of breast cancer is possible but should be investigated further.
Key words: breast cancer/cohort study/fertility drugs/infertility/risk factors
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  A. Jensen, H. Sharif, J. H. Olsen, and S. K. Kjaer Risk of Breast Cancer and Gynecologic Cancers in a Large Population of Nearly 50,000 Infertile Danish Women Am. J. Epidemiol., July 1, 2008; 168(1): 49 - 57. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. A. Azim, M. Costantini-Ferrando, and K. Oktay Safety of Fertility Preservation by Ovarian Stimulation With Letrozole and Gonadotropins in Patients With Breast Cancer: A Prospective Controlled Study J. Clin. Oncol., June 1, 2008; 26(16): 2630 - 2635. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 I. Pappo, L. Lerner-Geva, A. Halevy, L. Olmer, S. Friedler, A. Raziel, M. Schachter, and R. Ron-El The Possible Association between IVF and Breast Cancer Incidence Ann. Surg. Oncol., April 1, 2008; 15(4): 1048 - 1055. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
L. R. Schover Premature Ovarian Failure and Its Consequences: Vasomotor Symptoms, Sexuality, and Fertility J. Clin. Oncol., February 10, 2008; 26(5): 753 - 758. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Jensen, H. Sharif, E. I. Svare, K. Frederiksen, and S. K. Kjaer Risk of Breast Cancer After Exposure to Fertility Drugs: Results from a Large Danish Cohort Study Cancer Epidemiol. Biomarkers Prev., July 1, 2007; 16(7): 1400 - 1407. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. L. Terry, W. C. Willett, J. W. Rich-Edwards, and K. B. Michels A Prospective Study of Infertility Due to Ovulatory Disorders, Ovulation Induction, and Incidence of Breast Cancer Arch Intern Med, December 11, 2006; 166(22): 2484 - 2489. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 O. Reich and S. Regauer Do drugs that stimulate ovulation increase the risk for endometrial stromal sarcoma? Hum. Reprod., April 1, 2005; 20(4): 1112 - 1112. [Full Text] [PDF]
|
|