Hum. Reprod. Advance Access originally published online on August 19, 2004
Human Reproduction 2004 19(11):2523-2528; doi:10.1093/humrep/deh485
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Impact of overweight and underweight on assisted reproduction treatment
1 Department of Obstetrics and Gynaecology, Rikshospitalet University Hospital, Oslo, Norway
2 To whom correspondence should be addressed at: Department of Obstetrics and Gynaecology, Rikshospitalet University Hospital, Sognsvannsveien 20, 0027 Oslo, Norway. Email: peter.fedorcsak{at}klinmed.uio.no
BACKGROUND: Underweight and overweight may affect reproduction and interfere with treatment of infertility. The purpose of this report is to describe the independent effect of body weight on treatment with IVF and ICSI. METHODS: Records of 5019 IVF or ICSI treatments in 2660 couples were reviewed. The influence of body mass index (BMI) on treatment outcome was examined, after accounting for differences in age and infertility diagnosis. RESULTS: The cumulative live birth rate within three treatment cycles was 41.4% [95% confidence interval (CI) 32.1–50.7] in obese women with BMI 
30 kg/m2 and 50.3 (95% CI 47.0–53.7) in normal weight women with BMI 18.5–24.9 kg/m2. Obesity was associated with an increased risk of early pregnancy loss occurring before 6 weeks gestation. Positive correlation between BMI and gonadotrophin requirement during stimulation and negative correlation between BMI and number of collected oocytes were observed. Underweight (BMI <18.5 kg/m2) was not related to an impaired outcome of IVF or ICSI. CONCLUSIONS: Obesity is associated with lower chances for live birth after IVF and ICSI and with an impaired response to ovarian stimulation.
Key words: body mass index/insulin resistance/IVF/PCOS
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. L. Sneed, M. L. Uhler, H. E. Grotjan, J. J. Rapisarda, K. J. Lederer, and A. N. Beltsos Body mass index: impact on IVF success appears age-related Hum. Reprod., May 24, 2008; (2008) den188v1. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 C. E. Minge, B. D. Bennett, R. J. Norman, and R. L. Robker Peroxisome Proliferator-Activated Receptor-{gamma} Agonist Rosiglitazone Reverses the Adverse Effects of Diet-Induced Obesity on Oocyte Quality Endocrinology, May 1, 2008; 149(5): 2646 - 2656. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. METWALLY, W. L. LEDGER, and T. C. LI Reproductive Endocrinology and Clinical Aspects of Obesity in Women Ann. N.Y. Acad. Sci., April 1, 2008; 1127(1): 140 - 146. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Z. Veleva, A. Tiitinen, S. Vilska, C. Hyden-Granskog, C. Tomas, H. Martikainen, and J. S. Tapanainen High and low BMI increase the risk of miscarriage after IVF/ICSI and FET Hum. Reprod., April 1, 2008; 23(4): 878 - 884. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Maheshwari, L. Stofberg, and S. Bhattacharya Effect of overweight and obesity on assisted reproductive technology a systematic review Hum. Reprod. Update, September 1, 2007; 13(5): 433 - 444. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
M.F.G. Verberg, M.J.C. Eijkemans, N.S. Macklon, E.M.E.W. Heijnen, B.C.J.M. Fauser, and F.J. Broekmans Predictors of low response to mild ovarian stimulation initiated on cycle day 5 for IVF Hum. Reprod., July 1, 2007; 22(7): 1919 - 1924. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.F. Homan, M. Davies, and R. Norman The impact of lifestyle factors on reproductive performance in the general population and those undergoing infertility treatment: a review Hum. Reprod. Update, May 1, 2007; 13(3): 209 - 223. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
P. Fedorcsak, M. Raki, and R. Storeng Characterization and depletion of leukocytes from cells isolated from the pre-ovulatory ovarian follicle Hum. Reprod., April 1, 2007; 22(4): 989 - 994. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G.H. Woldringh, M.H.A. Frunt, J.A.M. Kremer, and M.E.A. Spaanderman Decreased ovarian reserve relates to pre-eclampsia in IVF/ICSI pregnancies Hum. Reprod., November 1, 2006; 21(11): 2948 - 2954. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
G. G. Gosman, H. I. Katcher, and R. S. Legro Obesity and the role of gut and adipose hormones in female reproduction Hum. Reprod. Update, September 1, 2006; 12(5): 585 - 601. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Dokras, L. Baredziak, J. Blaine, C. Syrop, B. J. VanVoorhis, and A. Sparks Obstetric outcomes after in vitro fertilization in obese and morbidly obese women. Obstet. Gynecol., July 1, 2006; 108(1): 61 - 69. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
The ESHRE Capri Workshop Group Nutrition and reproduction in women Hum. Reprod. Update, May 1, 2006; 12(3): 193 - 207. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
V. Martinet, Y. Manigart, S. Rozenberg, B. Becker, M. Gerard, and A. Delvigne Ovarian response to stimulation of HIV-positive patients during IVF treatment: a matched, controlled study Hum. Reprod., May 1, 2006; 21(5): 1212 - 1217. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. Thurin, T. Hardarson, J. Hausken, B. Jablonowska, K. Lundin, A. Pinborg, and C. Bergh Predictors of ongoing implantation in IVF in a good prognosis group of patients Hum. Reprod., July 1, 2005; 20(7): 1876 - 1880. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
A. K. Omland, T. Abyholm, P. Fedorcsak, G. Ertzeid, N. B. Oldereid, S. Bjercke, and T. Tanbo Pregnancy outcome after IVF and ICSI in unexplained, endometriosis-associated and tubal factor infertility Hum. Reprod., March 1, 2005; 20(3): 722 - 727. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
E. V. Younglai, A. C. Holloway, and W. G. Foster Environmental and occupational factors affecting fertility and IVF success Hum. Reprod. Update, January 1, 2005; 11(1): 43 - 57. [Abstract] [Full Text] [PDF]
|
|