Skip Navigation


Hum. Reprod. Advance Access originally published online on August 6, 2004
Human Reproduction 2004 19(11):2550-2554; doi:10.1093/humrep/deh447
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
19/11/2550    most recent
deh447v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (21)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Kolibianakis, E.M.
Right arrow Articles by Devroey, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Kolibianakis, E.M.
Right arrow Articles by Devroey, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction vol. 19 no. 11 © European Society of Human Reproduction and Embryology 2004; all rights reserved

Should we advise patients undergoing IVF to start a cycle leading to a day 3 or a day 5 transfer?

E.M. Kolibianakis1, K. Zikopoulos, W. Verpoest, M. Camus, H. Joris, A.C. Van Steirteghem and P. Devroey

Centre for Reproductive Medicine, Dutch-Speaking Brussels Free University, Laarbeeklaan 101, 1090 Brussels, Belgium

1 To whom correspondence should be addressed. Email: stratis{at}easynet.be

BACKGROUND: The aim of this study was to compare ongoing pregnancy rates per started cycle between patients randomized at consultation to have embryo transfer either on day 3 or on day 5 of in-vitro culture. METHODS: All patients <43 years of age for whom IVF was indicated were allowed to participate in the study (day 3 group, 234 patients; day 5 group, 226 patients). Ovarian stimulation was performed either using GnRH antagonists/recombinant FSH (rFSH) (day 3, 70.1% of patients; day 5, 72.6% of patients) or using the long GnRH agonist protocol/urinary gonadotropins (day 3, 29.9% of patients; day 5 27.4% of patients). RESULTS: The random decision to initiate a cycle leading to day 5 as compared with a day 3 transfer was associated with a significantly lower chance of embryo cryopreservation (day 3, 61.5%; day 5, 50.4%; P<0.02). Ongoing pregnancy rate per started cycle did not differ between the two groups compared [day 3, 32.1%, 95% confidence interval (CI) 26.4–38.2%; day 5, 33.2%, 95% CI 27.3–39.5%]. CONCLUSIONS: Advising patients at consultation to initiate an IVF cycle leading to a day 5 as compared with a day 3 transfer does not appear to increase the probability of ongoing pregnancy, and is associated with a significantly lower probability of obtaining cryopreserved embryos.

Key words: blastocyst transfer/day 3 transfer/GnRH antagonists/ongoing pregnancy rate/recombinant FSH


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
A. De Vos, C. Staessen, M. De Rycke, W. Verpoest, P. Haentjens, P. Devroey, I. Liebaers, and H. Van de Velde
Impact of cleavage-stage embryo biopsy in view of PGD on human blastocyst implantation: a prospective cohort of single embryo transfers
Hum. Reprod., December 1, 2009; 24(12): 2988 - 2996.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
W. Verpoest, P. Haentjens, M. De Rycke, C. Staessen, K. Sermon, M. Bonduelle, P. Devroey, and I. Liebaers
Cumulative reproductive outcome after preimplantation genetic diagnosis: a report on 1498 couples
Hum. Reprod., November 1, 2009; 24(11): 2951 - 2959.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
C. Staessen, W. Verpoest, P. Donoso, P. Haentjens, J. Van der Elst, I. Liebaers, and P. Devroey
Preimplantation genetic screening does not improve delivery rate in women under the age of 36 following single-embryo transfer
Hum. Reprod., December 1, 2008; 23(12): 2818 - 2825.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
F. Belva, S. Henriet, E. Van den Abbeel, M. Camus, P. Devroey, J. Van der Elst, I. Liebaers, P. Haentjens, and M. Bonduelle
Neonatal outcome of 937 children born after transfer of cryopreserved embryos obtained by ICSI and IVF and comparison with outcome data of fresh ICSI and IVF cycles
Hum. Reprod., October 1, 2008; 23(10): 2227 - 2238.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
A. De Vos, L. Van Landuyt, H. Van Ranst, A. Vandermonde, V. D'Haese, J. Sterckx, P. Haentjens, P. Devroey, and J. Van der Elst
Randomized sibling-oocyte study using recombinant human hyaluronidase versus bovine-derived Sigma hyaluronidase in ICSI patients
Hum. Reprod., August 1, 2008; 23(8): 1815 - 1819.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
W. Verpoest, M. De Rademaeker, K. Sermon, M. De Rycke, S. Seneca, E. Papanikolaou, C. Spits, L. Van Landuyt, J. Van der Elst, P. Haentjens, et al.
Real and expected delivery rates of patients with myotonic dystrophy undergoing intracytoplasmic sperm injection and preimplantation genetic diagnosis
Hum. Reprod., July 1, 2008; 23(7): 1654 - 1660.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
V. Goossens, M. De Rycke, A. De Vos, C. Staessen, A. Michiels, W. Verpoest, A. Van Steirteghem, C. Bertrand, I. Liebaers, P. Devroey, et al.
Diagnostic efficiency, embryonic development and clinical outcome after the biopsy of one or two blastomeres for preimplantation genetic diagnosis
Hum. Reprod., March 1, 2008; 23(3): 481 - 492.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. G. Papanikolaou, E. M. Kolibianakis, H. Tournaye, C. A Venetis, H. Fatemi, B. Tarlatzis, and P. Devroey
Live birth rates after transfer of equal number of blastocysts or cleavage-stage embryos in IVF. A systematic review and meta-analysis
Hum. Reprod., January 1, 2008; 23(1): 91 - 99.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. Van den Abbeel, U. Schneider, J. Liu, Y. Agca, J. K Critser, and A. Van Steirteghem
Osmotic responses and tolerance limits to changes in external osmolalities, and oolemma permeability characteristics, of human in vitro matured MII oocytes
Hum. Reprod., July 1, 2007; 22(7): 1959 - 1972.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
P. Donoso, C. Staessen, B.C.J.M. Fauser, and P. Devroey
Current value of preimplantation genetic aneuploidy screening in IVF
Hum. Reprod. Update, January 1, 2007; 13(1): 15 - 25.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
L. Gianaroli, M.C. Magli, A.P. Ferraretti, M. Lappi, E. Borghi, and B. Ermini
Oocyte euploidy, pronuclear zygote morphology and embryo chromosomal complement
Hum. Reprod., January 1, 2007; 22(1): 241 - 249.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. G. Papanikolaou, E. D'haeseleer, G. Verheyen, H. Van de Velde, M. Camus, A. Van Steirteghem, P. Devroey, and H. Tournaye
Live birth rate is significantly higher after blastocyst transfer than after cleavage-stage embryo transfer when at least four embryos are available on day 3 of embryo culture. A randomized prospective study
Hum. Reprod., November 1, 2005; 20(11): 3198 - 3203.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. Van den Abbeel, M. Camus, G. Verheyen, L. Van Waesberghe, P. Devroey, and A. Van Steirteghem
Slow controlled-rate freezing of sequentially cultured human blastocysts: an evaluation of two freezing strategies
Hum. Reprod., October 1, 2005; 20(10): 2939 - 2945.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.