Hum. Reprod. Advance Access originally published online on August 6, 2004
Human Reproduction 2004 19(11):2644-2647; doi:10.1093/humrep/deh451
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Embryo loss pattern is predominant in miscarriages with normal chromosome karyotype among women with repeated miscarriage
Department of Obstetrics and Gynecology, Hokkaido University Graduate School of Medicine, Kita-ku N15 W7, Sapporo 060-8638, Japan
2 To whom correspondence should be addressed. Email: yhideto{at}med.hokudai.ac.jp
OBJECTIVE: The aim of this study was to assess pregnancy loss patterns in women with repeated miscarriage (RM), according to fetal chromosome karyotypes and aetiologies of RM. METHODS: In this cohort study, 168 fetal chromosome karyotypes of miscarriages were investigated. The pregnancy loss patterns were compared between 75 miscarriages from RM women who had a history of two or more consecutive miscarriages and 93 miscarriages from control women whose previous pregnancies ended in live births without a history of RM. By serial ultrasonography, embryo loss (EL) was defined as miscarriage before fetal heat movement was identified and fetal loss (FL) as miscarriage after fetal heat movement was identified. The EL rate was calculated as EL/(EL+FL). RESULTS: The EL rate (66.7%) in miscarriages with normal karyotypes among RM women (n=42) was higher (P<0.05) than that (45.7%) in controls (n=46), while the EL rate (30.3%) in miscarriages with abnormal karyotypes among RM women (n=33) did not differ from that (25.5%) in the controls (n=47). The EL rate (71.4%) in miscarriages with normal karyotypes among unexplained RM women (n=21) was much higher (P<0.05) than that in the controls. CONCLUSIONS: By evaluating fetal karyotypes, we demonstrated for the first time that EL was predominant in miscarriages with normal karyotype among RM women.
Key words: chromosome karyotype/embryo loss/recurrent spontaneous abortion/repeated miscarriage/ultrasonography
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. Jauniaux, R. G. Farquharson, O. B. Christiansen, N. Exalto, and On behalf of ESHRE Special Interest Group for Earl Evidence-based guidelines for the investigation and medical treatment of recurrent miscarriage Hum. Reprod., September 1, 2006; 21(9): 2216 - 2222. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
R. G. Farquharson, E. Jauniaux, N. Exalto, and on behalf of the ESHRE Special Interest Group for Updated and revised nomenclature for description of early pregnancy events Hum. Reprod., November 1, 2005; 20(11): 3008 - 3011. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
J. H. Check Recurrent miscarriage and embryonic loss Hum. Reprod., July 1, 2005; 20(7): 2035 - 2036. [Full Text] [PDF]
|
|
|
|
|
|
H. Yamada and M. Morikawa Reply to 'Recurrent miscarriage and embryonic loss' Hum. Reprod., July 1, 2005; 20(7): 2036 - 2037. [Full Text] [PDF]
|
|