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Hum. Reprod. Advance Access originally published online on January 29, 2004
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Human Reproduction, Vol. 19, No. 3, 470-471, March 2004
© 2004 European Society of Human Reproduction and Embryology

Assessment of ovarian reserve. Is there still a role for ovarian biopsy?

First do no harm!

Fady I. Sharara1,2 and Richard T. Scott3

1 Virginia Center for Reproductive Medicine, Reston, VA and 2 George Washington University, Washington, DC, 3 Reproductive Medicine Associates of New Jersey, Morristown, NJ, USA

To whom correspondence should be addressed at: 11150 Sunset Hills Road, Suite 100, Reston, VA 20190, USA. E-mail: RScott{at}rmanj.com

Multiple endocrine, ultrasound-based and dynamic tests have been proposed for the assessment of ovarian reserve. Lately, ovarian biopsy has been proposed as a more representative functional test of ovarian reserve, and has been recommended as an early step in the investigation of infertility. Central to this hypothesis is the idea that a random biopsy of the ovarian cortex is reflective of the actual ovarian follicular pool. Recent studies have shown a wide variation in the number and distribution of ovarian follicles even from the same ovary and in the same patient. Coupled with the invasiveness of performing the biopsy and the risk of adhesion formation, we believe that there should not be a role for ovarian biopsy in ovarian reserve testing.

Key words: ovarian biopsy/ovarian reserve testing


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