Hum. Reprod. Advance Access originally published online on February 27, 2004
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Human Reproduction, Vol. 19, No. 4, 899-904,
April 2004
© 2004 European Society of Human Reproduction and Embryology
The number of retrieved oocytes does not decrease during consecutive gonadotrophin-stimulated IVF cycles
1 Department of Epidemiology, Netherlands Cancer Institute, Plesmanlaan 121, 1066 CX Amsterdam, 2 International Health Foundation, Europalaan 506, 3526 KS, Utrecht, 3 Department of Gynaecology and Obstetrics, Erasmus Medical Center Rotterdam, Postbus 2040, 3000 CA, Rotterdam, 4 Department of Public Health, Erasmus Medical Center, University Medical Center Rotterdam, Postbus 1738, 3000 DR, Rotterdam and 5 Department of Reproductive Medicine, Division of Obstetrics, Neonatology and Gynaecology, University Medical Center Utrecht, Postbus 85500, 3508 GA, Utrecht, The Netherlands
6 To whom correspondence should be addressed. e-mail: f.v.leeuwen{at}nki.nl
BACKGROUND: Our aim was to study whether there is a decreasing trend in the number of retrieved oocytes in women who had all undergone at least seven consecutive IVF cycles. METHODS: A nationwide retrospective cohort study was conducted among women whose first IVF cycle was stimulated with gonadotrophins in The Netherlands between 1983 and 1995. Among these eligible women, we identified all women who had received at least seven consecutive IVF cycles (n = 330). Poisson regression analysis was used to assess the trend in the number of retrieved oocytes over the first six IVF cycles. RESULTS: The unadjusted results showed a slight but non-significant decrease in the number of retrieved oocytes over six IVF cycles. The change in cycle 6 compared with cycle 1 was –0.06 oocytes (5.8% decrease) (P = 0.21). When adjusting for the number of ampoules and the stimulation protocol (fertility drug used combined with use of GnRH agonists), there was a considerable and highly significant decrease from cycle 1 to cycle 6 [change in cycle 6 compared with cycle 1: –0.19 oocytes (17.4% decrease), (P < 0.0001)]. However, when adjusting for age of the women, this decrease almost completely disappeared [change in cycle 6 compared with cycle 1: –0.05 oocytes (5% decrease), (P = 0.50)]. CONCLUSION: The results suggest that there is no decrease in the number of retrieved oocytes over subsequent cycles when simultaneously accounting for the increasing age of the women, differences in the number of ampoules of gonadotrophins used, type of stimulation protocol and year of IVF treatment.
Key words: consecutive cycles/IVF/ovarian response
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  E. M. Kolibianakis and P. Devroey No decrease occurs in the number of COCs retrieved with repeated IVF cycles Hum. Reprod., August 1, 2004; 19(8): 1927 - 1928. [Full Text] [PDF]
|
|