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Hum. Reprod. Advance Access originally published online on April 22, 2004
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Human Reproduction, Vol. 19, No. 6, 1239-1241, June 2004
© 2004 European Society of Human Reproduction and Embryology

What is the most relevant standard of success in assisted reproduction?

Is BESST (birth emphasizing a successful singleton at term) truly the best?

Georg Griesinger1,2, Konstantinos Dafopoulos1, Askan Schultze-Mosgau1, Ricardo Felberbaum1 and Klaus Diedrich1

1 Department of Obstetrics and Gynecology, Medical University of Schleswig-Holstein, Campus Luebeck, Ratzeburger Allee 160, D-23538 Luebeck, Germany

2 To whom correspondence should be addressed. e-mail: georg.griesinger{at}frauenklinik.uni-luebeck.de

There is much variability and no consensus on the definition of the most relevant outcome parameter after assisted reproduction technology (ART). Descriptive reports, such as annual statistics from national registries on the success of ART programmes, should present treatment success in terms of live birth per ovarian stimulation started, as this is the most relevant information for patients and doctors alike. Addressing concerns about the high rate of multiple pregnancies, rescaling the outcome of ART in large programmes and national audits to the singleton, live birth, might trigger a global change of attitude towards elective single embryo transfer in addition to any legal restrictions imposed. For clinical studies, the outcome measure will depend on the hypothesis tested, and investigators should remain free to choose the appropriate primary outcome measure.

Key words: assisted reproduction/outcome measures/success rates


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