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Human Reproduction, Vol. 19, No. 6, 1448-1449, June 2004
© 2004 European Society of Human Reproduction and Embryology

Live birth with sperm cryopreserved for 21 years prior to cancer treatment: Case report

G. Horne1,3, A.D. Atkinson1, E.H.E. Pease1, J.P. Logue2, D.R. Brison1 and B.A. Lieberman1

1 Department of Reproductive Medicine, St Mary’s Hospital, Manchester M13 0JH and 2 Department of Clinical Oncology, Christie Hospital, Manchester, UK

3 To whom correspondence should be addressed. e-mail: greg.horne{at}cmmc.nhs.uk

Advances in cancer treatment have led to significant improvements in the likelihood of reaching remission and long-term survival for men. Chemo- and radiotherapy-induced infertility are significant treatment side effects. Cryopreservation before the start of treatment enables sperm to be stored, thereby preserving the man’s potential fertility. Here, we describe the successful use (with ICSI) of sperm cryopreserved prior to cancer treatment, for a total of 21 years. We believe this to be the longest period of sperm cryopreservation, resulting in a live birth, so far reported in the literature.

Key words: ART/cancer/cryopreserved/sperm


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