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Hum. Reprod. Advance Access originally published online on May 27, 2004
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Human Reproduction, Vol. 19, No. 7, 1608-1611, July 2004
© 2004 European Society of Human Reproduction and Embryology

In vitro maturation and fertilization of oocytes from an intact ovary of a surgically treated patient with endometrial carcinoma: Case report

A. Revel1, A. Safran1, A. Benshushan1, A. Shushan1, N. Laufer1 and A. Simon1

In vitro Fertilization Unit, Department of Obstetrics and Gynecology, Hadassah University Hospital, Ein Kerem, PO Box 12000, Jerusalem 91120, Israel

1 To whom correspondence should be addressed. e-mail: revel{at}md.huji.ac.il

Polycystic ovary syndrome (PCOS) with prolonged anovulation had resulted in endometrial carcinoma in a 43-year-old woman. Since she and her husband did not share common biological children, they requested fertility preservation. Due to the woman’s age, high dose progesterone and postponing surgery were both considered inappropriate. We therefore proposed oocyte retrieval from the ovaries removed by staging laparotomy followed by in vitro maturation and ICSI. Surrogacy could then enable a future pregnancy. Fourteen of 17 (82%) retrieved oocytes matured in vitro. Following ICSI, eight embryos (two at the pronuclear stage and six cleaved) were cryopreserved. To the best of our knowledge, this is the first report of oocyte aspiration, maturation and fertilization from an ovary removed by laparotomy.

Key words: embryo cryopreservation/endometrial carcinoma/fertility preservation/in vitro maturation/polycystic ovary syndrome


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