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Hum. Reprod. Advance Access originally published online on May 27, 2004
Human Reproduction 2004 19(8):1821-1825; doi:10.1093/humrep/deh324
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Human Reproduction vol. 19 no. 8 © European Society of Human Reproduction and Embryology 2004; all rights reserved

A combination of interleukin-6 and its soluble receptor impairs sperm motility: implications in infertility associated with endometriosis

Souichi Yoshida1, Tasuku Harada, Tomio Iwabe, Fuminori Taniguchi, Masahiro Mitsunari, Nobuhiro Yamauchi, Imari Deura, Sayako Horie and Naoki Terakawa

Department of Obstetrics and Gynecology, Tottori University School of Medicine, Yonago 683-8504, Japan

1 To whom correspondence should be addressed. Email: souichi{at}grape.med.tottri-u.ac.jp

BACKGROUND: We previously reported that the level of interleukin (IL)-6 is increased in the peritoneal fluid of women with endometriosis. This study was undertaken to assess the effects of IL-6 and soluble IL-6 receptor (sIL-6R) on in vitro sperm motility. METHODS: Sperm (n=20) were cultured with IL-6 or sIL-6R, or with a combination of both. After 24 h cultures, sperm motility was evaluated using a computer-assisted semen analysis system. Gene and protein expressions of IL-6, IL-6 receptor (IL-6R), and glycoprotein 130 (gp130) were examined in sperm by RT–PCR analysis and western blot analysis. RESULTS: Addition of IL-6 or sIL-6R individually to the culture media had no affect on sperm motion. However, adding a combination of IL-6 and sIL-6R dose-dependently reduced the percentage of motile and rapidly moving sperm. Adding anti-IL-6R antibody abolished these adverse effects. Sperm expressed the gp130 gene and protein, but not IL-6 or IL-6R. CONCLUSIONS: A combination of IL-6 and sIL-6R may be associated with gp130 expressed in the sperm and reduce sperm motility. IL-6 and sIL-6R may contribute to the pathogenesis of endometriosis-associated infertility.

Key words: glycoprotein 130/interleukin-6/soluble interleukin-6 receptor/sperm motility/peritoneal fluid


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