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Hum. Reprod. Advance Access originally published online on June 10, 2004
Human Reproduction 2004 19(8):1867-1870; doi:10.1093/humrep/deh345
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Human Reproduction vol. 19 no. 8 © European Society of Human Reproduction and Embryology 2004; all rights reserved

Evidence of parthenogenetic origin of ovarian teratoma: Case report

Flávio Garcia Oliveira1,4, Dmitri Dozortsev1, Michael Peter Diamond2, Adriana Fracasso1, Soraya Abdelmassih1, Vicente Abdelmassih1, Sergio Pereira Gonçalves1, Roger Abdelmassih1 and Zolt Peter Nagy3

1 Clínica e Centro de Pesquisa em Reprodução Humana ‘Roger Abdelmassih’, São Paulo, Brazil, 2 Hutzel Hospital, Wayne State University, Detroit, MI and 3 Reproductive Biology Associates, 1150 Lake Hearn Dr Suite 600, Atlanta, GA 30342, USA

4 To whom correspondence should be adressed at: Clínica e Centro de Pesquisa em Reprodução Humana ‘Roger Abdelmassih’. Rua Maestro Elias Lobo, 805; 01433-000, São Paulo-SP, Brazil. Email: flaviogo2{at}uol.com.br

This case report represents one of the few documented cases of parthenote embryo retrieval from an IVF patient with a history of ovarian teratomas. A 29-year-old woman presented at our centre with a history of primary infertility for 6 years due to male factor. She had undergone left oophorectomy 4 years before due to an ovarian teratoma. An ultrasound scan performed during basal evaluation revealed two complex images in the right ovary suggesting teratomas, measuring 2.5 x 2.4 and 1.7 x 1.3 cm. A significant extent of sonographically normal ovarian parenchyma was present, and the patient underwent the long leuprolide acetate protocol of ovarian stimulation with recombinant FSH for an IVF-ICSI cycle. She had 13 metaphase II (MII), four metaphase I (MI), two germinal vesicle (GV) oocytes and one 4-cell embryo retrieved. Eight out of nine injected oocytes were fertilized normally while one was unfertilized. Embryo transfer was carried out 72 h after retrieval. The 4-cell (parthenote) embryo recovered at oocyte retrieval continued to cleave in culture, developing into a 7-cell embryo by the next day. The embryo was morphologically normal, presenting an evident nucleus in each blastomere. Fluorescent in situ hybridization (FISH) returned two signals for the X chromosome in each blastomere that was analysed. Of the eight normally fertilized embryos, three were transferred, resulting in a normal singleton pregnancy and the birth of a healthy baby.

Key words: embryo/FISH/IVF-ICSI/ovarian teratoma/parthenogenetic oocyte activation


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