Skip Navigation


Hum. Reprod. Advance Access originally published online on June 10, 2004
Human Reproduction 2004 19(9):1979-1984; doi:10.1093/humrep/deh369
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
19/9/1979    most recent
deh369v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (42)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Cédrin-Durnerin, I.
Right arrow Articles by Hugues, J.N.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cédrin-Durnerin, I.
Right arrow Articles by Hugues, J.N.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction vol. 19 no. 9 © European Society of Human Reproduction and Embryology 2004; all rights reserved

Recombinant human LH supplementation during GnRH antagonist administration in IVF/ICSI cycles: a prospective randomized study

I. Cédrin-Durnerin1,4, D. Grange-Dujardin2, A. Laffy2, I. Parneix3, N. Massin1, J. Galey1, L. Théron1, J.P. Wolf1, C. Conord2, P. Clément2, S. Jayot3 and J.N. Hugues1

1 Centre for Reproductive Medicine, Jean Verdier Hospital, A.P.-H.P., 93143 Bondy – University Paris XIII, 2 ART Centre, Clinique du Blanc Mesnil, 93150 Le Blanc Mesnil and 3 IVF Centre, Aquitaine Santé Médecine de la Reproduction, 33 523 Bruges Cedex, France

4 To whom correspondence should be addressed. Email: isabelle.cedrin-durnerin{at}jvr.ap-hop-paris.fr

BACKGROUND: When administered in the late follicular phase to prevent an LH surge, GnRH antagonists induce a sharp decrease in serum LH levels that may be detrimental for assisted reproductive technology cycle outcome. Therefore, a prospective study was designed to assess the effects of recombinant human (r)LH supplementation during GnRH antagonist (cetrorelix) administration. METHODS: The protocol consisted of cycle programming with oral contraceptive pill, ovarian stimulation with rFSH and flexible administration of a single dose of cetrorelix (3 mg). A total of 218 patients from three IVF centres were randomized (by sealed envelops or according to woman's birth date) to receive (n=114) or not (n=104) a daily injection of rLH 75 IU from GnRH antagonist initiation to hCG injection. RESULTS: The only significant difference was a higher serum peak E2 level in patients treated with rLH (1476±787 versus 1012±659 pg/ml, P<0.001) whereas the numbers of oocytes and embryos as well as the delivery rate (25.2 versus 24%) and the implantation rate per embryo (19.1 versus 17.4%) were similar in both groups. CONCLUSIONS: These results show that in an unselected group of patients, there is no evident benefit to supplement GnRH antagonist-treated cycles with rLH.

Key words: assisted reproductive technology/controlled ovarian stimulation/GnRH antagonist/rLH


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Hum ReprodHome page
E. Bosch, C. Vidal, E. Labarta, C. Simon, J. Remohi, and A. Pellicer
Highly purified hMG versus recombinant FSH in ovarian hyperstimulation with GnRH antagonists--a randomized study
Hum. Reprod., June 25, 2008; (2008) den220v1.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
J.A. Huirne, R. Homburg, and C.B. Lambalk
Are GnRH antagonists comparable to agonists for use in IVF?
Hum. Reprod., November 1, 2007; 22(11): 2805 - 2813.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
E.M. Kolibianakis, L. Kalogeropoulou, G. Griesinger, E.G. Papanikolaou, J. Papadimas, J. Bontis, and B.C. Tarlatzis
Among patients treated with FSH and GnRH analogues for in vitro fertilization, is the addition of recombinant LH associated with the probability of live birth? A systematic review and meta-analysis
Hum. Reprod. Update, September 1, 2007; 13(5): 445 - 452.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
B.C. Tarlatzis, B.C. Fauser, E.M. Kolibianakis, K. Diedrich, P. Devroey, and , On Behalf of the Brussels GnRH Antagonist Consen
GnRH antagonists in ovarian stimulation for IVF
Hum. Reprod. Update, July 1, 2006; 12(4): 333 - 340.
[Abstract] [Full Text] [PDF]

Home page
 Endocr. Rev.Home page
N. S. Macklon, R. L. Stouffer, L. C. Giudice, and B. C. J. M. Fauser
The Science behind 25 Years of Ovarian Stimulation for in Vitro Fertilization
Endocr. Rev., April 1, 2006; 27(2): 170 - 207.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
E. M. Kolibianakis, E. G. Papanikolaou, M. Camus, H. Tournaye, A. C. Van Steirteghem, and P. Devroey
Effect of oral contraceptive pill pretreatment on ongoing pregnancy rates in patients stimulated with GnRH antagonists and recombinant FSH for IVF. A randomized controlled trial
Hum. Reprod., February 1, 2006; 21(2): 352 - 357.
[Abstract] [Full Text] [PDF]

Home page
 Hum Reprod UpdateHome page
E.M. Kolibianakis, J. Collins, B. Tarlatzis, E. Papanikolaou, and P. Devroey
Are endogenous LH levels during ovarian stimulation for IVF using GnRH analogues associated with the probability of ongoing pregnancy? A systematic review
Hum. Reprod. Update, January 1, 2006; 12(1): 3 - 12.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
G. Griesinger, A. Schultze-Mosgau, K. Dafopoulos, A. Schroeder, A. Schroer, S. von Otte, D. Hornung, K. Diedrich, and R. Felberbaum
Recombinant luteinizing hormone supplementation to recombinant follicle-stimulating hormone induced ovarian hyperstimulation in the GnRH-antagonist multiple-dose protocol
Hum. Reprod., May 1, 2005; 20(5): 1200 - 1206.
[Abstract] [Full Text] [PDF]

Home page
 Hum ReprodHome page
L.-P. Cheung, P.-M. Lam, I. H. Lok, T. T.-Y. Chiu, S.-Y. Yeung, C.-C. Tjer, and C. J. Haines
GnRH antagonist versus long GnRH agonist protocol in poor responders undergoing IVF: a randomized controlled trial
Hum. Reprod., March 1, 2005; 20(3): 616 - 621.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.