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Hum. Reprod. Advance Access originally published online on June 10, 2004
Human Reproduction 2004 19(9):1979-1984; doi:10.1093/humrep/deh369
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Human Reproduction vol. 19 no. 9 © European Society of Human Reproduction and Embryology 2004; all rights reserved

Recombinant human LH supplementation during GnRH antagonist administration in IVF/ICSI cycles: a prospective randomized study

I. Cédrin-Durnerin1,4, D. Grange-Dujardin2, A. Laffy2, I. Parneix3, N. Massin1, J. Galey1, L. Théron1, J.P. Wolf1, C. Conord2, P. Clément2, S. Jayot3 and J.N. Hugues1

1 Centre for Reproductive Medicine, Jean Verdier Hospital, A.P.-H.P., 93143 Bondy – University Paris XIII, 2 ART Centre, Clinique du Blanc Mesnil, 93150 Le Blanc Mesnil and 3 IVF Centre, Aquitaine Santé Médecine de la Reproduction, 33 523 Bruges Cedex, France

4 To whom correspondence should be addressed. Email: isabelle.cedrin-durnerin{at}jvr.ap-hop-paris.fr

BACKGROUND: When administered in the late follicular phase to prevent an LH surge, GnRH antagonists induce a sharp decrease in serum LH levels that may be detrimental for assisted reproductive technology cycle outcome. Therefore, a prospective study was designed to assess the effects of recombinant human (r)LH supplementation during GnRH antagonist (cetrorelix) administration. METHODS: The protocol consisted of cycle programming with oral contraceptive pill, ovarian stimulation with rFSH and flexible administration of a single dose of cetrorelix (3 mg). A total of 218 patients from three IVF centres were randomized (by sealed envelops or according to woman's birth date) to receive (n=114) or not (n=104) a daily injection of rLH 75 IU from GnRH antagonist initiation to hCG injection. RESULTS: The only significant difference was a higher serum peak E2 level in patients treated with rLH (1476±787 versus 1012±659 pg/ml, P<0.001) whereas the numbers of oocytes and embryos as well as the delivery rate (25.2 versus 24%) and the implantation rate per embryo (19.1 versus 17.4%) were similar in both groups. CONCLUSIONS: These results show that in an unselected group of patients, there is no evident benefit to supplement GnRH antagonist-treated cycles with rLH.

Key words: assisted reproductive technology/controlled ovarian stimulation/GnRH antagonist/rLH


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