Skip Navigation


Hum. Reprod. Advance Access originally published online on June 30, 2004
Human Reproduction 2004 19(9):2076-2083; doi:10.1093/humrep/deh349
This Article
Right arrow Full Text Freely available
Right arrow FREE Full Text (PDF ) Freely available
Right arrow All Versions of this Article:
19/9/2076    most recent
deh349v1
Right arrow Submit a response
Right arrow Alert me when this article is cited
Right arrow Alert me when eLetters are posted
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in ISI Web of Science
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (17)
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Ruhayel, Y.
Right arrow Articles by Giwercman, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Ruhayel, Y.
Right arrow Articles by Giwercman, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Human Reproduction vol. 19 no. 9 © European Society of Human Reproduction and Embryology 2004; all rights reserved

Androgen receptor gene GGN and CAG polymorphisms among severely oligozoospermic and azoospermic Swedish men

Yasir Ruhayel1,2,5, Kristina Lundin1,2, Yvonne Giwercman2, Christer Halldén3, Marianne Willén4 and Aleksander Giwercman1,2

1 Fertility Centre, Scanian Andrology Centre, 2 Department of Urology, 3 Department of Clinical Chemistry, Malmö University Hospital, Lund University, Malmö and 4 Slottstadens läkarhus, Fågelbacksgatan 11, Malmö, Sweden

5 To whom correspondence should be addressed at: Wallenberg Laboratory, 4th Floor, Entrance 46, Malmö University Hospital, SE-205 02 Malmö, Sweden. Email: yasir.ruhayel{at}kir.mas.lu.se

BACKGROUND: We investigated the androgen receptor gene GGN polymorphism and its relation to male infertility and receptor function. METHODS: Ninety-nine infertile patients with sperm counts ≤5x106/ml were screened for karyotypic abnormalities and Y-chromosome microdeletions. The GGN and CAG repeats were sequenced in those without genetic abnormalities and in 223 controls. RESULTS: Five men (5.1%) carried Y-chromosome microdeletions and five had abnormal karyotypes. Neither the distributions of GGN nor of CAG differed significantly between patients and controls. However, the <21 CAG and GGN=23 combination of repeats occurred more frequently in the controls (16%) compared to the entire group of patients (4%; P=0.003) and to the subgroup of 54 patients with idiopathic infertility (4%; P=0.02). Testicular volume and CAG lengths were higher (P=0.04 and 0.002 respectively) among the patients with GGN=23 compared to GGN=24. The odds ratio (OR) of having low prostatic secretory function was higher among patients with GGN=24 than those with GGN=23 (OR: 3.5; 95% CI: 1.1–11.7; P=0.04). CONCLUSIONS: The <21 CAG and GGN=23 combination of repeats may confer a lower risk of infertility to the carriers. Androgen sensitivity may be higher among carriers of the GGN=23 allele compared to the GGN=24 allele.

Key words: androgen receptor/infertility/microdeletion/polymorphism/Y chromosome


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 J AndrolHome page
W. A. Badran, I. Fahmy, W. M. Abdel-Megid, K. Elder, R. Mansour, and M. Kent-First
Length of Androgen Receptor-CAG Repeats in Fertile and Infertile Egyptian Men
J Androl, July 1, 2009; 30(4): 416 - 425.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
S. G. Martinez-Garza, M. C. Gallegos-Rivas, M. Vargas-Maciel, J. M. Rubio-Rubio, M. E. de los Monteros-Rodriguez, C. Gonzalez-Ortega, P. Cancino-Villarreal, L. G. V. de Lara, and A. M. Gutierrez-Gutierrez
Genetic Screening in Infertile Mexican Men: Chromosomal Abnormalities, Y Chromosome Deletions, and Androgen Receptor CAG Repeat Length
J Androl, November 1, 2008; 29(6): 654 - 660.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
C. A. Davis-Dao, E. D. Tuazon, R. Z. Sokol, and V. K. Cortessis
Male Infertility and Variation in CAG Repeat Length in the Androgen Receptor Gene: A Meta-analysis
J. Clin. Endocrinol. Metab., November 1, 2007; 92(11): 4319 - 4326.
[Abstract] [Full Text] [PDF]

Home page
 J Mol EndocrinolHome page
F. F Brockschmidt, M. M Nothen, and A. M Hillmer
The two most common alleles of the coding GGN repeat in the androgen receptor gene cause differences in protein function
J. Mol. Endocrinol., July 1, 2007; 39(1): 1 - 8.
[Abstract] [Full Text] [PDF]

Home page
 J AndrolHome page
S. Rajender, V. Rajani, N. J. Gupta, B. Chakravarty, L. Singh, and K. Thangaraj
No Association of Androgen Receptor GGN Repeat Length Polymorphism With Infertility in Indian Men
J Androl, November 1, 2006; 27(6): 785 - 789.
[Abstract] [Full Text] [PDF]

Home page
 Eur J EndocrinolHome page
K B Lundin, Y L Giwercman, L Rylander, L Hagmar, and A Giwercman
Androgen receptor gene GGN repeat length and reproductive characteristics in young Swedish men.
Eur. J. Endocrinol., August 1, 2006; 155(2): 347 - 354.
[Abstract] [Full Text] [PDF]

Home page
 J. Clin. Endocrinol. Metab.Home page
K. B. Lundin, A. Nordenskjold, A. Giwercman, and Y. L. Giwercman
Frequent Finding of the Androgen Receptor A645D Variant in Normal Population
J. Clin. Endocrinol. Metab., August 1, 2006; 91(8): 3228 - 3231.
[Abstract] [Full Text] [PDF]


Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.