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Human Reproduction, Vol. 2, No. 7, pp. 569-571, 1987
© 1987 European Society of Human Reproduction and Embryology

research-article

Pregnancies after IVF when high tonic LH is reduced by long-term treatment with GnRH agonists

Michael C. Macnamee1, Clin M. Howles1 and Robert G. Edwards1,2

1Bourn Hall Clinic Bourn, Cambridge CB3 7TR 2Physiological Laboratory, University of Cambridge Downing Street, Cambridge CB2 3EG, UK

Some patients show high output of urinary LH when superovulated with clomiphene citrate and HMG. Recent evidence has shown that this is detrimental to successful IVF. By the use of an GnRH analogue we have managed to ameliorate this condition and successfully establish pregnancy in these women. Further, the association between failure of IVF-ER and elevated levels of LH may explain the aetiology of some ‘idiopathically’ infertile couples.

Key words: urinary LH/clomiphene citrate/HMG/IVF/GnRH


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E.M. Kolibianakis, K. Zikopoulos, J. Schiettecatte, J. Smitz, H. Tournaye, M. Camus, A.C. Van Steirteghem, and P. Devroey
Profound LH suppression after GnRH antagonist administration is associated with a significantly higher ongoing pregnancy rate in IVF
Hum. Reprod., November 1, 2004; 19(11): 2490 - 2496.
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