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Hum. Reprod. Advance Access originally published online on October 28, 2004
Human Reproduction 2005 20(1):216-220; doi:10.1093/humrep/deh582
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Human Reproduction vol. 20 no. 1 © European Society of Human Reproduction and Embryology 2004; all rights reserved

High frequency of gr/gr chromosome Y deletions in consecutive oligospermic ICSI candidates

Maite de Llanos1, José Luís Ballescà3, Cristina Gázquez1, Ester Margarit2 and Rafael Oliva1,2,4

1 Grup de Genètica Humana, Departament de Ciències Fisiològiques I, Faculty of Medicine, University of Barcelona, 2 Servei de Genètica, Hospital Clínic i Provincial de Barcelona, IDIBAPS, 08036 Barcelona and 3 Obstretics and Ginecology Unit, Hospital Clínic i Provincial of Barcelona, IDIBAPS, 08036 Barcelona, Spain

4 To whom correspondence should be addressed at: Grup de Genètica Humana, Departament de Ciències Fisiològiques I, Facultat de Medicina, Casanova 143, 08036 Barcelona, Spain. Email: roliva{at}ub.edu

BACKGROUND: The Y chromosome gr/gr microdeletion eliminates two copies of the DAZ gene and several additional transcriptional units and has been associated as a risk factor for infertility. Our objective was to study the presence of the gr/gr deletion in ICSI candidates in our population and to determine whether the laboratory, clinical and ICSI outcome were different in the gr/gr deleted patients. METHODS: Two hundred and eighty-three ICSI candidates were studied. Semen analysis, serum FSH, LH, testosterone, inhibin B, karyotype and detection of sequence tagged sites in the Y chromosome were performed. RESULTS: gr/gr deletions were detected in 11 (5.07%) of 217 oligospermic and in one (1.52%) of 66 azoospermic consecutive ICSI candidates, but in none of 232 controls (P=0.002). The fertility rate was not different in the four patients of the gr/gr deleted group treated by ICSI (64.38%; 47/73) as compared to average results at our center (65.49%; 2393/3654). CONCLUSIONS: gr/gr deletions are a risk factor for spermatogenic failure at our population, but the prognosis of the four patients of the gr/gr deleted group treated by ICSI is not different from that of other ICSI patients.

Key words: azoospermia/gr/gr deletion/ICSI treatment/oligospermia/Y chromosome


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