Hum. Reprod. Advance Access originally published online on June 24, 2005
Human Reproduction 2005 20(10):2776-2783; doi:10.1093/humrep/dei122
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Andrology |
Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality
1 Department of Genetics and Reproduction, Veterinary Research Institute, Brno, Czech Republic, 2 National Center for Environmental Assessment, Office of Research and Development, US EPA, Washington, DC, 3 Department of Chemistry and Biochemistry, South Dakota State University, Brookings, SD, USA, 4 Institute of Hygiene, Brno, Czech Republic, 5 Center for Occupational and Environmental Health, University of California Los Angeles, Los Angeles, CA and 6 Reproductive Toxicology Division, National Health and Environmental Effects Research Laboratory, Office of Research and Development, US EPA, Research Triangle Park, NC, USA
7 To whom correspondence should be addressed at: US EPA (MD-72), Research Triangle Park, NC 27711, USA. E-mail: Darney.sally{at}epa.gov
BACKGROUND: This study examined potential associations between exposure to episodes of air pollution and alterations in semen quality. The air pollution, resulting from combustion of coal for industry and home heating in the Teplice district of the Czech Republic, was much higher during the winter than at other times of year with peaks exceeding US air quality standards. METHODS: Young men from Teplice were sampled up to seven times over 2 years allowing evaluation of semen quality after periods of exposure to both low and high air pollution. Routine semen analysis (sperm concentration, motility and morphology) and tests for sperm aneuploidy and chromatin integrity were performed, comparing measurements within each subject. Exposure was classified as high or low based on data from ambient air pollution monitoring. RESULTS: Using repeated measures analysis, a significant association was found between exposure to periods of high air pollution (at or above the upper limit of US air quality standards) and the percentage of sperm with DNA fragmentation according to sperm chromatin structure assay (SCSA). Other semen measures were not associated with air pollution. CONCLUSION: Exposure to intermittent air pollution may result in sperm DNA damage and thereby increase the rates of male-mediated infertility, miscarriage, and other adverse reproductive outcomes.
Key words: air pollution/computer-aided sperm analysis/human semen/sperm aneuploidy/sperm chromatin structure assay
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  M. Joffe What has happened to human fertility? Hum. Reprod., November 19, 2009; (2009) dep390v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
C. de Jager, N.H. Aneck-Hahn, M.S. Bornman, P. Farias, G. Leter, P. Eleuteri, M. Rescia, and M. Spano Sperm chromatin integrity in DDT-exposed young men living in a malaria area in the Limpopo Province, South Africa Hum. Reprod., October 1, 2009; 24(10): 2429 - 2438. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zini and M. Sigman Are Tests of Sperm DNA Damage Clinically Useful? Pros and Cons J Androl, May 1, 2009; 30(3): 219 - 229. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
Y. Xia, P. Zhu, Y. Han, C. Lu, S. Wang, A. Gu, G. Fu, R. Zhao, L. Song, and X. Wang Urinary metabolites of polycyclic aromatic hydrocarbons in relation to idiopathic male infertility Hum. Reprod., May 1, 2009; 24(5): 1067 - 1074. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Leridon and R. Slama The impact of a decline in fecundity and of pregnancy postponement on final number of children and demand for assisted reproduction technology Hum. Reprod., June 1, 2008; 23(6): 1312 - 1319. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 K. Tremellen Oxidative stress and male infertility--a clinical perspective Hum. Reprod. Update, May 1, 2008; 14(3): 243 - 258. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
S. D. Perreault Reply: Episodic air pollution and sperm DNA fragmentation Hum. Reprod., December 1, 2007; 22(12): 3264 - 3264. [Full Text] [PDF]
|
|
|
|
|
|
M. Jafarabadi Episodic air pollution is associated with increased DNA fragmentation in human sperm without other changes in semen quality Hum. Reprod., December 1, 2007; 22(12): 3263 - 3263. [Full Text] [PDF]
|
|
|
|
 |
|
 A. Bhatnagar Environmental Cardiology: Studying Mechanistic Links Between Pollution and Heart Disease Circ. Res., September 29, 2006; 99(7): 692 - 705. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 A. Zini and J. Libman Sperm DNA damage: clinical significance in the era of assisted reproduction. Can. Med. Assoc. J., August 29, 2006; 175(5): 495 - 500. [Abstract] [Full Text] [PDF]
|
|