Hum. Reprod. Advance Access originally published online on June 24, 2005
Human Reproduction 2005 20(10):2904-2908; doi:10.1093/humrep/dei146
| ||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||||
Reproductive Genetic |
Vascular endothelial growth factor gene +405 C/G polymorphism is associated with susceptibility to advanced stage endometriosis
1 Department of Obstetrics and Gynecology, College of Medicine, University of Ulsan, Asan Medical Center and 2 Department of Obstetrics and Gynecology and 3 The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, Korea
4 To whom correspondence should be addressed at: Department of Obstetrics and Gynecology, The Institute of Reproductive Medicine and Population, Medical Research Center, Seoul National University College of Medicine, 28 Yungun-dong, Chongno-ku, Seoul 110–744, Korea. E-mail: ymchoi{at}snu.ac.kr
BACKGROUND: Vascular endothelial growth factor (VEGF) is known to play a pivotal role in the development of endometriosis. This study was performed to investigate whether the VEGF gene 5’-untranslated region polymorphism is associated with susceptibility to advanced stage endometriosis. METHODS: This study comprised 215 women with advanced stage endometriosis, 219 control women without endometriosis, and 70 fertile women. Following extraction of genomic DNA, genotyping of the –460 C/T and +405 C/G polymorphisms of the VEGF gene were performed by polymerase chain reaction (PCR) and restriction fragment length polymorphism (RFLP) analysis. RESULTS: The distribution of genotypes and allele frequencies of the –460 C/T polymorphism in the endometriosis group did not differ from those in the control group and the fertile women group. However, genotype distribution of the +405 C/G polymorphism was significantly different between patients with and without endometriosis (P = 0.01) and between patients with endometriosis and the fertile women (P = 0.02). Patients with endometriosis showed a higher incidence of the +405 CC genotype compared with the controls and the fertile women (P = 0.007 and 0.016 respectively). CONCLUSIONS: These findings suggest that the VEGF +405 C/G polymorphism may be associated with the risk of advanced stage endometriosis in the Korean population.
Key words: angiogenesis/endometriosis/polymorphism/VEGF
CiteULike 
Connotea 
Del.icio.us What's this?
This article has been cited by other articles:
|
|
 |
|
  Q. Liu, Y. Li, J. Zhao, D.-L. Sun, Y.-N. Duan, N. Wang, R.-M. Zhou, and S. Kang Association of polymorphisms -1154G/A and -2578C/A in the vascular endothelial growth factor gene with decreased risk of endometriosis in Chinese women Hum. Reprod., June 16, 2009; (2009) dep208v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Kim, S. Y. Ku, S. H. Kim, G. H. Lee, Y. M. Choi, J. M. Kim, T. H. Lee, and S. Y. Moon Endothelial nitric oxide synthase gene Glu298Asp polymorphism is associated with advanced stage endometriosis Hum. Reprod., June 16, 2009; (2009) dep212v1. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
H. Xu, W.T. Lui, C.Y. Chu, P.S. Ng, C.C. Wang, and M.S. Rogers Anti-angiogenic effects of green tea catechin on an experimental endometriosis mouse model Hum. Reprod., March 1, 2009; 24(3): 608 - 618. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 R. N. Taylor, Jie Yu, P. B. Torres, A. C. Schickedanz, J. K. Park, M. D. Mueller, and N. Sidell Mechanistic and Therapeutic Implications of Angiogenesis in Endometriosis Reproductive Sciences, February 1, 2009; 16(2): 140 - 146. [Abstract] [PDF]
|
|
|
|
 |
|
 C.B. Tempfer, M. Simoni, B. Destenaves, and B.C.J.M. Fauser Functional genetic polymorphisms and female reproductive disorders: Part II--endometriosis Hum. Reprod. Update, January 1, 2009; 15(1): 97 - 118. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 Z. Z. Zhao, D. R. Nyholt, S. Thomas, S. A. Treloar, and G. W. Montgomery Polymorphisms in the vascular endothelial growth factor gene and the risk of familial endometriosis Mol. Hum. Reprod., September 1, 2008; 14(9): 531 - 538. [Abstract] [Full Text] [PDF]
|
|
|
|
|
|
D. Gentilini, E. Somigliana, P. Vigano, M. Vignali, M. Busacca, and A. M. Di Blasio The vascular endothelial growth factor +405G>C polymorphism in endometriosis Hum. Reprod., January 1, 2008; 23(1): 211 - 215. [Abstract] [Full Text] [PDF]
|
|
|
|
 |
|
 M. K. Tee, J.-L. Vigne, and R. N. Taylor All-Trans Retinoic Acid Inhibits Vascular Endothelial Growth Factor Expression in a Cell Model of Neutrophil Activation Endocrinology, March 1, 2006; 147(3): 1264 - 1270. [Abstract] [Full Text] [PDF]
|
|