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Hum. Reprod. Advance Access originally published online on June 24, 2005
Human Reproduction 2005 20(10):2958-2963; doi:10.1093/humrep/dei154
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© The Author 2005. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oupjournals.org

Gynaecology

Expression of interleukin-8 and monocyte chemotactic protein-1 in adenomyosis

E. Cagnur Ulukus1,2, Murat Ulukus3,4, Yasemin Seval3,5, Wenxin Zheng1 and Aydin Arici3,6

Yale University School of Medicine, Departments of 1 Pathology and 3 Obstetrics and Gynecology, New Haven, CT, USA, 2 Dokuz Eylul University School of Medicine, Department of Pathology, Inciralti, Izmir, 4 Ege University School of Medicine, Department of Obstetrics & Gynecology, Bornova, Izmir, and 5 Akdeniz University School of Medicine, Department of Histology and Embryology, Antalya, Turkey

6 To whom correspondence should be addressed at: Section of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Yale University School of Medicine, New Haven, CT 06520-8063, USA. Tel: +1-203-785-3581; Fax: +1-203-785-7134; E-mail: aydin.arici{at}yale.edu

BACKGROUND: To clarify the inflammatory nature of adenomyosis, we aimed to investigate the expression of interleukin-8 (IL-8) and monocyte chemotactic protein-1 (MCP-1) by immunohistochemistry to determine their putative role in pathophysiology of adenomyosis. METHODS: Adenomyosis samples, with their eutopic endometrium, were collected from 30 women undergoing hysterectomy. Endometrium from 27 women without adenomyosis were also collected as a control group. Samples were grouped according to the menstrual cycle phase and examined by immunohistochemistry for IL-8 and MCP-1. RESULTS: In normal endometrium, secretory phase samples expressed higher levels of epithelial IL-8 than in proliferative phase samples (P = 0.01), and we observed a trend for an increased epithelial MCP-1 expression in the secretory phase samples compared with the proliferative phase samples (P = 0.07). Endometrial samples of women with adenomyosis did not show the same cyclic variation. In the secretory phase, eutopic endometrium of women with adenomyosis expressed lower levels of epithelial IL-8 and MCP-1 compared with normal endometrium (P < 0.05). The expression of epithelial IL-8 and MCP-1 was higher in the adenomyosis foci than the eutopic endometrium (P < 0.05). CONCLUSIONS: These findings may indicate that an intrinsic abnormality of inflammatory response may be present in eutopic endometrium of women with adenomyosis, and IL-8 and MCP-1 may contribute to the pathophysiology of adenomyosis.

Key words: adenomyosis/endometriosis/endometrium/interleukin-8/monocyte chemotactic protein-1


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