Hum. Reprod. Advance Access originally published online on July 8, 2005
Human Reproduction 2005 20(11):3136-3140; doi:10.1093/humrep/dei185
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Encouraging results despite complexity of multidisciplinary care of HIV-infected women using assisted reproduction techniques
1 Centre d’AMP de Strasbourg, Service de Gynécologie-Obstétrique, CMCO-SIHCUS, 19 rue Louis Pasteur – BP 120 – 67303 Schiltigheim, 2 CISIH, Clinique Médicale A, Hôpital Civil, 67091 Strasbourg Cedex and 3 Centre d’AMP de Strasbourg, Service de Biologie de la Reproduction, CMCO-SIHCUS, 19 rue Louis Pasteur, 67303 Schiltigheim
4 To whom correspondence should be addressed. E-mail: jeanine.ohl{at}sihcus.fr
BACKGROUND: Assisted reproduction technologies can treat infertility for human immunodeficiency virus (HIV) seropositive women. We assessed the efficacy of these techniques in the results and difficulties encountered while conducting our assisted reproduction programme for 49 couples in which at least the woman had HIV infection that was currently under control. METHODS: Treatments included intrauterine insemination (IUI), IVF and ICSI, with ovarian stimulation. Embryos were transferred on day 3 after oocyte retrieval. An elective single transfer was performed, except for patients aged $ 40 years. RESULTS: The median age of the women was 36 years. Ten IUI, nine IVF, 53 ICSI and 10 frozen–thawed embryo transfers have been performed. No pregnancy occurred following the IUI trials but for the couples with IVF and ICSI attempts the clinical pregnancy rate per embryo transfer was 23.9%. Eight babies have been born leading to a 22.2% take home baby rate per treated couple. Contamination was not observed in any newborn. CONCLUSIONS: Assisted reproduction technologies and particularly ICSI can provide HIV seropositive women with a safe means of mothering children. Results are encouraging when considering the age of the patients and a preferential single embryo transfer.
Key words: assisted reproduction techniques/HIV/pregnancy
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