Hum. Reprod. Advance Access originally published online on July 21, 2005
Human Reproduction 2005 20(11):3204-3207; doi:10.1093/humrep/dei195
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Fertilization, cleavage and blastocyst development according to the maturation timing of oocytes in in vitro maturation cycles*
Maria Infertility Hospital, Sinseol-dong, Dongdaemun-gu, Seoul 121-742, Korea
1 To whom correspondence should be addressed at: McGill Reproductive Center, Department of Obstetrics and Gynecology, Royal Victoria Hospital, McGill University, Montreal, Quebec, Canada H3A 1A1. E-mail: weon-young.son{at}muhc.mcgill.ca
BACKGROUND: This study was to examine the developmental capacity of oocytes collected from an in vitro maturation (IVM) programme according to their maturation time. METHODS: The study included 47 IVM cycles that underwent blastocyst transfer. The patients (n = 38) were primed with 10 000 IU HCG 36 h before their oocyte retrieval. The oocytes were classified into three groups: group 1 (n = 139) where oocytes were matured on day of oocyte collection; group 2 (n = 627) where oocytes were matured on day 1 after IVM; group 3 (n = 163) where oocytes matured on day 2 after IVM. Fertilization, cleavage and blastocyst formation were compared between three groups. RESULTS: Rates of cleavage and blastocyst development in group 3 (72.2%, 96/133; 19.0%, 15/133) were significantly lower than those of group 1 (100%, 108/108; 58.3%, 63/108) and group 2 (91.5%, 487/532; 50.4%, 268/532) respectively (P < 0.01). The number of freezable good quality blastocysts among blastocysts developed from group 1 (52.4%, 33/63) was significantly higher than those from group 2 (35.4%, 95/268) and group 3 (6.7%, 1/15) (P < 0.01). There were 24 clinical pregnancies (51.1%, 24/47) after transfer of the blastocysts and 29 healthy babies were delivered. CONCLUSION: These results suggest that oocytes reaching metaphase II faster in an IVM programme have better embryonic developmental competence.
Key words: blastocyst/HCG/immature oocytes/IVM/maturation time
* Presented at the Annual Meeting of the European Society of Human Reproduction and Embryology, Vienna, Austria, June 30–July 3, 2002.
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